During activities of the Sea Fisheries Research Institute at Kleinzee, lung samples from six South African fur seals were collected. The terminal airways showed pseudostratified ciliated columnar epithelium with numerous goblet cells and occasional brush cells. Smooth muscle, cartilage and submucosal glands were also present. The epithelium changed over a short distance, in the smaller airways,...

Background: Inflammatory bowel disease unclassified (IBDU) is considered to be an aberrant immune response with loss of tolerance to many antigens. Objective: This paper tries to address whether there is any value to test for auto-antibodies in such patients. Methods: 60 patients with inflammatory bowel disease unclassified participated in the study. Auto-antibodies to nuclear antigen, intestin...

Enteropeptidase (EP) is a serine proteinase and activates trypsinogen to trypsin, thus playing an important role in food digestion. Nevertheless, the localization of EP is still controversial, likely due to a lack of studies using specific antibodies against EP. The aim of this study was to define cellular localization of EP in human duodenum and expression in tumor cells at the duodenal region...

BACKGROUND Mammalian Anterior Gradient 2 (AGR2) is a protein disulfide isomerase that is required for the production of intestinal mucus and Paneth and goblet cell homeostasis. However, whether increased endoplasmic reticulum (ER) stress occurs in Agr2(-/-) mice remains a controversial issue. METHODOLOGY/PRINCIPAL FINDINGS We characterized the function of zebrafish agr2 by both morpholino ant...

Xian, C. J., G. S. Howarth, C. E. Mardell, J. C. Cool, M. Familari, L. C. Read, and A. S. Giraud. Temporal changes in TFF3 expression and jejunal morphology during methotrexate-induced damage and repair. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G785–G795, 1999.—Trefoil factor TFF3 has been implicated in intestinal protection and repair. This study investigated the spatiotemporal r...

Cells within the normal human colonic epithelium undergo a dynamic cycle of growth, differentiation, and death. The organotypic culture system of human fetal colonic epithelial cells seeded on top of collagen gels with embedded colonic fibroblasts allowed prolonged culture of the colonic epithelial cells (Kalabis J, Patterson MJ, Enders GM, Marian B, Iozzo RV, Rogler G, Gimotty PA, Herlyn M. FA...

The two major intestinal epithelial cell lineages are columnar fluid-absorbing cells and mucin-producing goblet cells. High levels of transforming growth factor (TGF) beta1 are found surrounding postmitotic cells in the colonic crypt, suggesting that TGF-beta1 mediates the maturation and growth inhibition of both epithelial cell types. However, we now show that the injection of recombinant TGF-...

The morphology of the midgut epithelium cells of Anticarsia gemmatalis (Hübner) larvae is described by light and transmission electron microscopy. The midgut of A. gemmatalis is the largest portion of the digestive tract, with three distinct regions: proximal, media and distal. Its wall is formed by pseudostratified columnar epithelial tissue having four cell types: columnar, goblet, regenerati...

In the large intestine, multipotent stem cells are located at base of crypt and differentiate into three main cell types: enterocytes, goblet cells, enteroendocrine cells. Goblet cells’ function is synthesis secretion mucins. Genetic epigenetic changes that provide survival advantages for or progenitor resulting in deregulation cellular differentiation major causes all carcinomas. Our laborator...

The airway epithelium comprises of different cell types and acts as a physical barrier preventing pathogens, including inhaled particles microbes, from entering the lungs. Goblet cells submucosal glands produce mucus that traps which are expelled respiratory tract by ciliated cells. Basal act progenitor cells, differentiating into epithelial types, to maintain homeostasis following injury. Adhe...