نتایج جستجو برای: gm1

تعداد نتایج: 1944  

Journal: :Biochimica et biophysica acta 1993
M J Parr M B Bally P R Cullis

The incorporation of ganglioside GM1 or phosphatidylethanolamine-polyethyleneglycol conjugates into liposomes can result in extended circulation lifetimes in vivo. This has been attributed to an ability to avoid uptake by the reticuloendothelial system (RES), specifically the phagocytic cells of the liver and spleen. Here we examine whether a representative large unilamellar vesicle (LUV) formu...

Journal: :Journal of clinical microbiology 1982
B Gustafsson R Möllby

Human and porcine enterotoxigenic strains of Escherichia coli were cultivated in tryptone-yeast extract medium or brain heart infusion broth and tested for production of heat-labile enterotoxin by the GM1 ganglioside enzyme-linked immunosorbent assay (GM1-ELISA) and the Y1 adrenal cell assay. When testing for enterotoxigenicity by the GM1-ELISA technique, homologous antisera for human and porci...

Journal: :Investigative ophthalmology & visual science 1992
E Yoles M Zalish V Lavie R Duvdevani S Ben-Bassat M Schwartz

This study demonstrates the earliest reported effects of GM1 treatment on crush-injured axons of the mammalian optic nerve. GM1, administered intraperitoneally immediately after injury, was found to reduce the injury-induced metabolic deficit in nerve activity within 2 hr of injury, as measured by changes in the nicotine-amine adenine dinucleotide redox state. After 4 wk, transmission electron ...

Journal: :Arquivos de neuro-psiquiatria 2011
Leonardo Caixeta

mg (normal range 78-280), confirming the diagnosis of GM1 Gangliosidosis. Type 3 GM1 gangliosidosis is characterized by onset around the second decade of life with slowly progressive extrapiramidal signs, such as dystonia and parkinsonism. There is also a high prevalence of gait disturbance and dysarthria. Other symptoms are short stature, bone abnormalities, cognitive impairment, ataxia and ca...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1991
W Kielczynski L C Harrison P J Leedman

Gangliosides were extracted from purified human and porcine thyrotropin (TSH) receptors (TSH-R) and were detected by probing with an 125I-labeled sialic acid-specific lectin, Limax flavus agglutinin. Gangliosides copurified with human and porcine TSH-R migrated between monosialoganglioside GM1 and disialoganglioside GD1a. Ceramide glycanase digestion of the purified human TSH-R-associated glyco...

Journal: :Polskie Archiwum Medycyny Wewnetrznej 2016
Magdalena Przybylska-Feluś Małgorzata Zwolińska-Wcisło Agnieszka Piątek-Guziewicz Agata Furgała Kinga Sałapa Tomasz Mach

INTRODUCTION Celiac disease (CD) is an immune-mediated enteropathy related to permanent gluten intolerance, characterized by gastrointestinal symptoms as well as nongastrointestinal symptoms, including neurologic ones. The presence of neuron-specific enolase (NSE), interleukin 10 (IL-10), and antiganglioside M1 (anti-GM1) antibodies has been demonstrated for neurologic conditions as well as imm...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Marco Rusnati Chiara Urbinati Elena Tanghetti Patrizia Dell'Era Hugues Lortat-Jacob Marco Presta

Free gangliosides bind fibroblast growth factor 2 (FGF2), thus preventing cell interaction and biological activity of the growth factor in endothelial cells. Here we investigated the role of cell-associated gangliosides in mediating the biological activity of FGF2. Treatment of endothelial cells of different origin with the ganglioside biosynthesis inhibitors fumonisin B1, D-threo-1-phenyl-2-de...

Journal: :Infection and immunity 1998
M M Prendergast A J Lastovica A P Moran

Three Campylobacter jejuni, biotype 2, serotype O:41 strains that were isolated from patients who developed Guillain-Barré syndrome (GBS) and one C. jejuni isolate from a patient who developed enteritis only were examined. The aim of the study was to determine the structure of the core oligosaccharide (OS) of the lipopolysaccharide (LPS) of C. jejuni serotype O:41, a serotype rarely associated ...

Journal: :Acta neurobiologiae experimentalis 1990
F Casamenti F Milan G Pepeu

Three- and fifteen-month old rats with a unilateral ibotenic acid lesion of the nucleus basalis magnocellularis (NBM) were used. In 3-month old rats, 4 days after the lesion a 34 and 33% decrease in high affinity choline uptake (HACU) rate was found in the ipsilateral frontal and parietal cortices, respectively. Twenty-one days later the lesioned rats showed a loss in the NBM choline acetyltran...

Journal: :Developmental cell 2014
Roy Cohen Danielle E Buttke Atsushi Asano Chinatsu Mukai Jacquelyn L Nelson Dongjun Ren Richard J Miller Moshe Cohen-Kutner Daphne Atlas Alexander J Travis

Membrane lipid regulation of cell function is poorly understood. In early development, sterol efflux and the ganglioside GM1 regulate sperm acrosome exocytosis (AE) and fertilization competence through unknown mechanisms. Here, we show that sterol efflux and focal enrichment of GM1 trigger Ca(2+) influx necessary for AE through CaV2.3, whose activity has been highly controversial in sperm. Sper...

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