OBJECTIVE This study investigated whether different psychosocial factors predicted levels of glycosylated hemoglobin (HbA1c) over time, after adjusting for covariates and baseline level of HbA1c. DESIGN These questions were investigated with a longitudinal sample (N = 97, age = 61-91) of older women without diabetes. HbA1c levels and psychosocial measures were obtained at baseline and 2-year ...

Under proper conditions, whole blood can be stored at room temperature for as long as 21 days before measurement of glycosylated hemoglobin by affinity chromatography. Whole blood (anticoagulated with EDTA or heparin) was placed in capillary tubes, which were then sealed at both ends and stored at room temperature. Just before assay, whole blood was rinsed from the tubes and diluted 10-fold wit...

The utility of glycosylated hemoglobin (HbA1) measurement as an index of chronic control in diabetes can be adversely affected by interference from a labile glycosylated fraction that changes rapidly with acute changes in blood glucose concentration. I used a "high-pressure" liquid-chromatographic assay and a newly developed electrophoretic assay to quantitate the contribution of this labile fr...

We estimated glycated ("glycosylated") hemoglobin in erythrocytes of hemodialyzed uremic patients by the aminophenylboronic acid affinity-chromatographic method and by an ion-exchange chromatographic method. As expected, apparent HbA1 concentrations were above normal in the uremic patients, owing to interference by the carbamylated hemoglobin. However, there was no significant difference betwee...

BACKGROUND Complications increase treatment costs of diabetes mellitus (DM). An adequate metabolic control of the disease could reduce these costs. AIM To evaluate the costs of medical care for a cohort of patients with DM, according to their degree of metabolic compensation. MATERIAL AND METHODS All diabetic patients attended in a regional hospital from 2005 to 2010 were analyzed. A correl...

Glycation is the nonenzymatic addition of sugar to amino groups of proteins. While virtually any protein in the body can be glycated, for convenience and ease of obtaining a sample, glycated hemoglobin is measured in the blood obtained from a patient. Blood glucose concentrations exhibit wide diurnal fluctuations due to food ingestion, exercise, and other factors. In contrast, the concentration...

OBJECTIVE The goal of this study was to describe medication usage patterns in patients with type 2 diabetes mellitus (T2DM) initiating treatment with non-insulin antidiabetic drugs (NIADs), basal insulin, or prandial/mixed insulin using real-world data. RESEARCH DESIGN AND METHODS A retrospective analysis using the Truven Health MarketScan Research Databases was conducted to identify adults (...

OBJECTIVE To investigate whether socioeconomic status and psychological well-being (eudaimonic and hedonic aspects) predicted nondiabetic levels of glycosylated hemoglobin (HbA1c) over time, after adjusting for covariates and baseline level of HbA1c. METHODS These questions were investigated with a longitudinal sample (n = 97; age = 61-91 years) of older women without diabetes. Socioeconomic ...

OBJECTIVES To evaluate the effects of GH replacement therapy (GHR) for 3 years on glycated haemoglobin (HbA1c) and on the presence of dysglycaemia at any time during follow-up in Spanish adult patients with growth hormone deficiency (GHD). STUDY DESIGN A retrospective study of 41 patients with GHD was conducted using baseline and long-term data. Changes in HbA1c values during the first 3 year...

OBJECTIVE To study insulin dependent diabetic patients for change in non-proliferative retinopathy and its relation to glycaemic control and to various clinical background data. DESIGN Prospective study with follow up for seven years. SETTING Outpatient departments of university hospitals. MAIN OUTCOME MEASURES Glycated haemoglobin concentration; degree of retinopathy. RESULTS Retinopat...