Studies show that inhalation of oil gas vapor may impose serious health risks for individuals exposed to such vapor. The main aim of this study was to determine the effects of diesel oil vapor inhalation on SGOT and SGPT as indices of liver function. Male Wistar rats were randomly divided into control animals, and rats that exposed to diesel oil vapor for 1 hour/day, for 2 hours/day and for 3 h...

The incidence of INH-associated liver injury was evaluated in 239 children aged between 9 and 14 years, who were receiving 300 mg INH/day for tuberculosis prophylaxis. Serum SGOT and SGPT levels were determined before INH administration and at 4-weekly intervals thereafter. Levels of both enzymes were raised during the first 3 months of treatment in 18 (7.5%) children, while in 23 (9.6%) childr...

Thirty six Large White Yorkshire gilts in the age group of 5 months were selected and randomly divided into 6 groups consisting of 6 animals each. Among these, 3 groups were reared under intensive and 3 groups under semi-intensive system of management. In each system group 1 devoid of antioxidants and treated as control, group 2 supplemented with Vitamin E 22IU and group 3 both Vitamin E 22IU a...

We tested the accuracy of the Reflotron System by comparing results given by this system for estimations of glucose, SGOT, SGPT, cholesterol and triglycerides on patients samples which were already analysed on either an autoanalyser HITACHI 705 or manually on CLIN ICON 4010. Reflotron estimations correlated well with both Hitachi and Clinicon estimations and the strips gave reproducible results...

PURPOSE We successfully developed recombinant human interferon alpha-2b (rhIFN- α 2b) and mutein forms through the site-directed mutagenesis technique. The mutein forms were developed by substituting cysteins at positions 2 and 99 with aspartic acids. The potential adverse effects of these rhIFN- α 2bs were assessed by acute and subchronic studies. METHODS In the acute study, rhIFN- α 2bs wer...

A transaminase (aminotransferase, EC 2.6.1) fraction was partially purified from shoot tips of pea (Pisum sativum L. cv. Alaska) seedlings. With alpha-ketoglutarate as co-substrate, the enzyme transaminated the following aromatic amino acids: d,l-tryptophan, d,l-tyrosine, and d,l-phenylalanine, as well as the following aliphatic amino acids: d,l-alanine, d,l-methionine, and d,l-leucine. Of othe...

Hepatoprotective activity of Emblica officinalis (EO) and Chyavanaprash (CHY) extracts were studied using carbon tetrachloride (CCl(4)) induced liver injury model in rats. EO and CHY extracts were found to inhibit the hepatotoxicity produced by acute and chronic CCl(4) administration as seen from the decreased levels of serum and liver lipid peroxides (LPO), glutamate-pyruvate transaminase (GPT...

Kynurenine transaminase activity in rat liver was found in both the mitochondrial and supernatant fractions. The mitochondrial and supernatant fractions contained (a) kynurenine-pyruvate transaminase, which showed a preference for pyruvate as amino acceptor and a pH optimum between 8.0 and 8.5, and (b) kynurenine-alpha-oxoglutarate transaminase, with a preference for alpha-oxoglutarate and a pH...

Increased glutamine metabolism is a hallmark of cancer. Mitochondrial glutamic pyruvate transaminase (GPT2) catalyzes the reversible transamination between alanine and α-ketoglutarate (α-KG), also known as 2-oxoglutarate, to generate pyruvate and glutamate during cellular glutamine catabolism. However, the precise role of GPT2 in tumorigenesis remains elusive. Here, we report that in breast can...

A glutamine transaminase has been purified from the soluble portion of rat kidney homogenate; this enzyme, designated as kidney glutamine transaminase K, has different catalytic and physical properties from those previously found for the purified soluble glutamine transaminase of rat liver (liver glutamine transaminase L). Liver glutamine transaminase L is highly active toward methionine, glyox...