To avoid the adverse effects of aprotinin (Apr) in autologous fibrin glue, we compared the inhibitory properties of four commercial anti-fibrinolytic agents (tranexamic acid (Tra), epsilon-aminocaproic acid (Ips), gabexate mesilate (Gab) and nafamostat mesilate (Naf)). The optimum conditions for the lysing of fibrin glue were an incubation temperature of 37 degrees C, and incubation medium cont...

PURPOSE To compare the effect of using fibrin glue or 10-0 nylon sutures on the clinical outcome of patients undergoing pterygium excision and conjunctival autografting. METHODS We retrospectively reviewed the medical records of 52 eyes from 46 patients who underwent pterygium excision and conjunctival autografting and were followed up for more than 3 months. The operation duration, postopera...

Biological glue is a natural adhesive generated by the interaction between fibrinogen (pre-glue) and thrombin to produce fibrin. The pre-glue is prepared from a single donor (to avoid the problems of pooled plasma) and stored as cryoprecipitate. Before being used it is thawed, dissolved in saline, and activated into an adhesive by the addition of topical thrombin. Biological glue was used proph...

BACKGROUND Mandibular plates may become exposed following radiation therapy, infection, and mucosal necrosis. This may lead to early removal of the mandibular plates with subsequent instability of bone fragments. OBJECTIVE To compare fibrin glue, a bioadhesive, with traditional sutures in closing mucosa over exposed mandibular plates in a cat. DESIGN Prospective matched-pairs analysis. SU...

BACKGROUND Axillary lymphadenectomy or sentinel biopsy is integral part of breast cancer treatment, yet seroma formation occurs in 15-85% of cases. Among methods employed to reduce seroma magnitude and duration, fibrin glue has been proposed in numerous studies with controversial results. METHODS Thirty patients over 60 years underwent quadrantectomy or mastectomy with level I/II axillary lym...

A citric acid derivative (CAD) with three active ester groups in a molecule was prepared in order to develop a novel tissue adhesive consisting of CAD and collagen (CAD-C glue). The bonding strength of CAD-C glue to porcine soft tissues had high value similar to the tearing strength of the original soft tissue. The cytotoxicity of CAD for L929 fibroblast was 10 times less cytotoxic than that of...

atrioventricular groove rupture is a rare, albeit mortal, complication following mitral valve surgery. avoidance is the best strategy but it cannot fully prevent the occurrence of this complication. several repair techniques have been described with varying success rates; however, the rarity of the complication precludes consensus about the safest technique. here we report two cases of posterio...

KFGS (Keratinocyte fibrin glue suspension) and FKFGS (Fibroblast keratinocyte fibrin glue suspension) methods were performed in this study. Materials and Methods: Four healthy adult horses were used in this study (350 ± 117). Fibroblast cells have been separated by explant culture method from neck, keratinocyte cells have been separated by enzyme digestion from lib skin samples and Fibrinogen h...