F the many substances that have been found to be mutagenic several are 0 also carcinogenic and considerable evidence has been accumulating to indicate a relationship between these two properties. Nitrogen and sulfur mustards were shown by AUERBACH and ROBSON (1944) to be mutagenic for Drosophila, a finding which has been confirmed by DEMEREC (1947a,b), BURDETTE (1952) and others. Nitrogen musta...

Vipul Kashyap, Kei-Hoi Cheung, Donald Doherty, Matthias Samwald, M. Scott Marshall, Joanne Luciano, Susie Stephens, Ivan Herman and Raymond Hookway Partners Healthcare System, Clinical Informatics R&D, 93 Worcester St, Suite 201, Welleley, MA, USA – [email protected] Yale Center for Medical Informatics, Yale University School of Medicine, 300 George Street, Suite 501, New Haven, CT, USA – ...

Glomus tumors are uncommon benign soft tissue neoplasms. We report the case of a 32-year-old male who presented with right upper lobe atelectasis due to an endobronchial tumor. The patient underwent right upper lobectomy and wedge bronchoplasty. The pathological diagnosis was bronchial glomus tumor. To our knowledge, this presentation (with right upper lobe atelectasis) has never before been re...

CONCLUSIONS Guild's initial 231 word report was the source of a stream of positive consequences; the glomus story is a paradigm of the utility of basic science. BACKGROUND The glomus tumor has had a number of different names, including glomus jugulare, glomus tympanicum, nonchromaffin paraganglioma, and carotid body tumor. Although they have occurred throughout the ages, glomus tumors were ne...

Glomus tumors are benign lesions of the middle ear which are slow growing in nature. They are the most common primary neoplasm of the middle ear [1]. Glomus tumor arises from abnormal growth of the paraganglion cells. The head and neck region represent the commonest area where extra adrenal paraganglioma also known as glomus tumors are found [2]. Patients may present with bleeding, pulsatile ti...

SUMMARY A case of recurrent glomus tympanicum presenting with epistaxis is described. CT and MR imaging revealed a homogeneously enhancing mass extending along the entire course of the eustachian tube, with a portion protruding into the nasopharynx. Glomus tumors tend to spread along the path of least resistance and may extend into the eustachian tube. The unique imaging appearance should place...

INTRODUCTION A glomus tumor is a rare, benign tumor with atypical clinical symptoms. Because of its small size, it is difficult to diagnose and treat early; therefore, it leads to poor quality of life. Glomus tumors are known to commonly affect the hand and rarely manifest in other areas. Because they simulate neuromas, hemangiomas, and neurofibromatosis, the differential diagnosis is difficult...

Carotid body chemoreceptors are complex secondary receptors. There are chemical and electric connections between glomus cells (GC/GC) and between glomus cells and carotid nerve endings (GC/NE). Chemical secretion of glomus cells is accompanied by GC/GC uncoupling. Chemical GC/NE transmission is facilitated by concomitant electric coupling. Chronic hypoxia reduces GC/GC coupling but increases G/...

Paragangliomas of the head and neck are usually benign tumors. Malignant form is quite rare and criteria for malignancy are not clear. Clinical, biochemical and histological features of malignant forms are not sufficient to reliably distinguish them from benign tumors and malignancy is established only in the presence of distant metastasis. Herein, we report a patient with glomus jugulare on th...

Glomangiosarcoma, or malignant glomus tumor, is a very rare neoplasm that when seen typically arises from a benign glomus tumor. Despite having histologic features of malignancy, these tumors usually do not metastasize. However, when metastasis occurs this disease is often fatal. We report a case of a malignant glomus tumor arising de novo on the nose of an 89-year-old white woman, and we revie...