Basement membrane has attracted less attention than the other components of connective tissue. But, like the other extracellular fibres and matrix materials, it can profoundly influence both the structure and function of advanced life forms. Usually taking the shape of thin, structureless cementing material between epithelial and connective tissue, basement membranes are widely distributed thro...

Bradykinin dilates efferent arterioles via release of efferent arteriole epoxyeicosatrienoic acids when perfused retrograde (no glomerular autacoids). However, when efferent arterioles are perfused orthograde through the glomerulus, bradykinin-induced dilatation is caused by a balance between: (1) the glomerular vasoconstrictor 20-hydroxyeicosatetraenoic acid and vasodilator prostaglandins, and...

BEEUWKES, REINIER III. E$ erent vascular patterns and early vasculartubular relations in the dog kidney. Am. J. Physiol. 221(5): 1361-1374. 197 1 .-Glomerular efferent vascular patterns were studied in cleared dog kidneys injected with silicone rubber. In addition, to show vascular-tubular relations, kidneys were perfusion-fixed in vivo and their vasculature was filled with silicone rubber. Pro...

The morphological basis of glomerular filtration and protein reabsorption in mouse kidney was examined by using mushroom tyrosinase subunits (mol wt 34,500), as an ultrastructural tracer. Almost immediately after injection tyrosinase reaction product was visualized in the glomerulus, and within the capillary lumen extending into the endothelial fenestrae. The entire basement membrane showed acc...

There is increasing evidence from both human and experimental studies that at least partial reversal of glomerulosclerosis can be achieved by glomerular remodeling. This requires substantial changes in glomerular architecture, specifically of glomerular capillaries. It was the purpose of the present study to characterize the stereologic and topologic characteristics of glomerular capillaries wh...