نتایج جستجو برای: glioblastoma multiforme

تعداد نتایج: 26725  

Journal: :Journal of Neuro-Oncology 1987

Journal: :Surgical Neurology International 2011

Journal: :The Scientific World JOURNAL 2011

Journal: :Cornea 2007
Hayyam Kiratli Ceren Poyraz Aytaç Gököz

PURPOSE To describe a patient with a sebaceous adenoma of the bulbar conjunctiva, a distinctly unusual site for this tumor, associated with glioblastoma multiforme and chronic lymphocytic leukemia. METHODS A 69-year-old woman presented with a red nodule on the temporal bulbar conjunctiva. The mass was excised. RESULTS Histopathologic examination of the tumor showed a sebaceous adenoma. With...

2015
Rui Li Xincheng Chen Yongping You Xiefeng Wang Yanwei Liu Qi Hu Wei Yan

Glioblastoma multiforme is the most common primary malignant brain tumor in adults. In addition to poor response to treatment, a high recurrence rate contributes to the poor prognosis. The purpose of this study was to investigate the genetical and clinical characteristics of recurrent glioblastoma. We used whole transcriptome sequencing data to examine the distribution of molecular subtypes and...

2016
Hua-Fu Zhao Jing Wang Hao-Ran Jiang Zhong-Ping Chen Shing-Shun Tony To

BACKGROUND Glioblastoma multiforme is the most aggressive malignant primary brain tumor, characterized by rapid growth and extensive infiltration to neighboring normal brain parenchyma. Both PI3K/Akt and JNK pathways are essential to glioblastoma cell survival, migration and invasion. Due to their hyperactivation in glioblastoma cells, PI3K and JNK are promising targets for glioblastoma treatme...

Journal: :Journal of the National Cancer Institute 2001
J S Smith I Tachibana S M Passe B K Huntley T J Borell N Iturria J R O'Fallon P L Schaefer B W Scheithauer C D James J C Buckner R B Jenkins

BACKGROUND Survival of patients with anaplastic astrocytoma is highly variable. Prognostic markers would thus be useful to identify clinical subsets of such patients. Because specific genetic alterations have been associated with glioblastoma, we investigated whether similar genetic alterations could be detected in patients with anaplastic astrocytoma and used to identify those with particularl...

Journal: :British journal of neurosurgery 2008
Giuseppe M V Barbagallo Michael D Jenkinson Andrew R Brodbelt

The surgical management of recurrent glioblastoma multiforme is controversial. Recent publications suggest that re-operation provides 3-5 months median survival, without significant increases in morbidity or mortality. Age (< or =50 years, although older patients may also benefit) and performance status (Karnofsky performance score > or =60-70) are the most important factors. Re-resection not o...

Journal: :Cancer research 1997
S I Wang J Puc J Li J N Bruce P Cairns D Sidransky R Parsons

Alterations of the PTEN gene occur in glioblastoma multiforme. To determine the frequency of PTEN alteration, 34 consecutive glioblastomas were studied in detail. Sequencing each of the nine exons amplified from tumor DNA revealed 11 mutations. Analysis of polymorphic markers within and surrounding the PTEN gene identified an additional four homozygous deletion mutations. Loss of heterozygosity...

2012
Sabiq Dipro Faisal Al-Otaibi Adel Alzahrani Anwar Ulhaq Essam Al Shail

Turcot syndrome (TS) is a rare hereditary disorder clinically characterized by the occurrence of primary tumors of the colon and the central nervous system (CNS). Here we present the case of an 11-year-old boy with a synchronous clinical presentation of both glioblastoma multiforme (GBM) and colonic adenocarcinoma. A molecular genetic study revealed microsatellite instability in the DNA mismatc...

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