Gingival overgrowth is a side effect of certain medications. The most fibrotic drug-induced lesions develop in response to therapy with phenytoin, the least fibrotic lesions are caused by cyclosporin A, and the intermediate fibrosis occurs in nifedipine-induced gingival overgrowth. Fibrosis is one of the largest groups of diseases for which there is no therapy but is believed to occur because o...

Antiphospholipid antibody (APLA) syndrome is a noninflammatory autoimmune disease, with innumerable clinical manifestations ranging from recurrent thrombosis and pregnancy morbidity to valvular lesions, transverse myelitis, thrombocytopenia, and hemolytic anemia. APLAs in antiphospholipid syndrome (APS) are well-known risk factors for cerebrovascular accidents. Stroke is the most common manifes...

Mod&r, Lavstedt, and Ahlund studied the oral health effects of smoking and snuff use in 232 Swedish school children ages 13 to 14 years (119 boys and 113 girls) (36). Thirteen (11 percent) of the boys used snuff. The children were interviewed regarding their tobacco and toothbrushing habits, and examin ers (blind to the interview results) clinically assessed the degree of gingival mflammation, ...

The experiments were performed in six beagle dogs fed a soft diet which allowed dental plaque formation. During a pre-experimental period of 7 weeks, periodontitis was induced by (1) surgically creating a bony pocket and (2) adapting a copper band to the exposed tooth surface. Two dogs were sacrificed at the end of this period and tissue sections were prepared for histological examination. In t...

Periodontal disease is a chronic and irreversible disease that affects the supporting tissue of the teeth (gums, alveolar bone, cementum and periodontal ligament). The disease is often divided into two conditions: gingivitis and periodontitis. Gingivitis is inflammation of the gingiva, while periodontitis is inflammation of non-gingival tissue: periodontal ligament and alveolar bone (Harvey CE,...

PURPOSE The purpose of this study was to evaluate the relationship between volatile sulfur compounds (VSC) and gingival health status and to determine if volatile sulfur compounds can detect early dental plaque-induced gingival disease. METHODS A split-mouth design with randomly selected quadrants of the mandibular arch enabled 39 participants to serve as their own controls. At baseline and a...

tory conditions of the gingival and underlying bone and connective tissue. Platelet-activating factor (PAF), a potent inflammatory phospholipid mediator that has been previously detected in elevated levels in inflamed gingival tissues, in gingival crevicular fluid and in saliva, is implicated in periodontal disease. Our results from previous studies showed that the biologically active phospholi...