BACKGROUND Ferrous sulfate drops are routinely used in Iran in infants older than 6 months of age. Effect of ferrous sulfate drops in preventive or therapeutic doses on gastrointestinal mucosa of infants is not studied as yet. Upper gastrointestinal complications due to acute iron poisoning are well known in this age group. In this article, we reviewed published articles on iron deposition in u...

OBJECTIVE To evaluate food intake, occurrence of energy-protein malnutrition and anemia, and intestinal iron absorption in children with chronic liver disease. METHODS The study included 25 children with chronic liver disease, 14 with cholestasis and 11 without cholestasis. The age varied between 6.5 months and 12.1 years. Intestinal iron absorption was evaluated by the increment of serum iro...

325 female students of zahedan at the average age of 16.2 years old (16-22) were randomly selected to study the prevalence of iron deficiency anemia. hb, hematocrit, mcv, mchc, iron, tibc and ferritin were measured. results showed that in the population studied 3.4%, 27.7%, 4.3%, 11.7%, 25.5%, 11.4% had their hb, mcv, serum iron, tranferrin saturation, ferritin respectively below the who standa...

PURPOSE Iron accumulation with age in the retinal pigment epithelium (RPE) may be one important source of oxidative stress that contributes to age-related macular degeneration (AMD). Young and old rodent RPE/choroid were compared to assess iron homeostasis during normal aging and the effects of increased iron on the functions of retinal pigment epithelial cells. METHODS The iron level, mRNA e...

Iron is essential to erythrocyte oxygen transport and is a catalyst for oxidative metabolism in all cells. Iron is absorbed by the duodenum and requires an acidic environment for optimal absorption. Iron is found for 70% in erythrocytes, and 30% in storage, and a small amount in myoglobin and cytochromes. Iron supplementation reduces anemia in breastfed infants and increases in significant dose...

BACKGROUND Primary iron overload in African Americans has been reported predominantly from autopsy studies. METHODS We characterized hepatic iron phenotypes in 83 African Americans who underwent liver biopsy during the interval 1990 to 1995. We tabulated pathology report form data, iron grades in hepatocytes (0-4) and Kupffer cells (0-3) and abnormal liver histology. Increased iron was define...

background: iron chelators are an important part of management of patients with thalassemia. it is prudent to compare efficacy of different iron chelators in treatment of iron overload in these patients who receive regular blood transfusion. we aimed to compare the efficacy and safety of available oral iron chelator; deferasirox (exjade®) with deferasirox (osveral®) in reducing iron overload in...

BACKGROUND The iron-regulatory hormone hepcidin has not been studied in infants, who experience large physiologic changes in iron status. OBJECTIVE The objective was to study hepcidin and erythropoietin and their correlation with iron status in iron-replete and iron-deficient low-birth-weight (LBW) infants-a group at particular risk of iron deficiency (ID). DESIGN We randomly assigned 285 o...