نتایج جستجو برای: ghs
تعداد نتایج: 917 فیلتر نتایج به سال:
[1] Geothermobarometric together with microand macro-structural data indicate ductile flow in the metamorphic core of the Himalaya in the Garhwal region of India. Peak metamorphic pressure and temperature increase dramatically across the Main Central Thrust (MCT) from !5 kbar and !550°C in the Lesser Himalayan Crystalline Sequence (LHCS) to !14 kbar and !850°C at !3 km above the MCT in the Grea...
Ghrelin, a recently described endogenous ligand for the growth hormone secretagogue receptor (GHS-R), is produced by stomach cells and is a potent circulating orexigen, controlling energy expenditure, adiposity, and growth hormone secretion. However, the functional role of ghrelin in regulation of immune responses remains undefined. Here we report that GHS-R and ghrelin are expressed in human T...
BACKGROUND Cachexia is a wasting condition associated with cancer types and, at the same time, is a serious and dose-limiting side effect of cancer chemotherapy. Skeletal muscle loss is one of the main characteristics of cachexia that significantly contributes to the functional muscle impairment. Calcium-dependent signaling pathways are believed to play an important role in skeletal muscle decl...
Glucose, xylose, and N-acetylglucosamine are elementary building blocks for disaccharides, oligomers, and polymers, as well as key molecules allowing fine modifications of many kinds of biological compounds. The highly diverse molecules containing these three sugars are ubiquitous components of the architecture of eukaryotic and prokaryotic cells and may also be involved in signaling between ce...
Objective: Chronic administration of GH secretagogues (GHSs) induces a state of positive energy balance in rodents by a GH-independent mechanism. Here we sought to determine to what extent the GHS effects to increase food intake and increase fat accumulation are glucocorticoid-dependent. Design: The effects of twice-daily s.c. injections of GH-releasing peptide-6 (GHRP-6) (250mg/kg) for 2 weeks...
Ghrelin is a gut-brain peptide hormone, which binds to the growth hormone secretagogue receptor (GHS-R) to regulate a wide variety of biological processes in fish. Despite these prominent physiological roles, no studies have reported the anatomical distribution of preproghrelin transcripts using in situ hybridization in a non-mammalian vertebrate, and its mapping within the different encephalic...
BACKGROUND Changes to the design of the General Household Survey (GHS) risk a discontinuity in the ONS Health Expectancy (HE) series. This report compares methodological approaches to ensure consistency of this important National Statistic and reports improvements to the methodology surrounding standard error (SE) estimation. METHODS A comparison of the use of cross-sectional and longitudinal...
Ghrelin, the 28 amino acid peptide recently identified as the natural ligand for the growth hormone (GH) secretagogue (GHS) receptor, has multiple activities in addition to stimulation of GH secretion, including stimulation of feeding and weight gain. To utilize these actions for potential therapeutic benefit, we have produced analogs of human ghrelin with enhanced metabolic stability, affinity...
BACKGROUND Non-communicable chronic diseases in Australia contribute to approximately 85% of the total burden of disease; this proportion is greater for Aboriginal communities. The Get Healthy Service (GHS) is effective at reducing lifestyle-based chronic disease risk factors among adults and was enhanced to facilitate accessibility and ensure Aboriginal cultural appropriateness. The purpose of...
Ghrelin is a novel gastrointestinal hormone produced by rat and human gastric X-like neuroendocrine cells, which strongly stimulates GH secretion and influences energy balance, gastric motility, and acid secretion. Ghrelin is expressed in pituitary and gastrointestinal endocrine tumors. It binds to the GH secretagogue receptor (GHS-R), which is present in a wide variety of central and periphera...
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