purpose it is well known that the effects of exercise training gives inter individual differences which might be due to genetic diversity. this study aims to explore the probable relation between angiotensin converting enzyme (ace) alleles and physical fitness parameters in elite athletes. methods twenty-nine national level indian army triathletes who volunteered for the study were taken as sub...

Objective: The effect of MYF5 gene polymorphism on body weight was investigated in 100 Friesian bull calves. Methodology: Blood samples were collected from each animal for DNA extraction. The PCR-TaqI digestion of 1190 bp of a fragment of MYF5 gene revealed that, two fragments (983 and 207 bp) for genotype BB, three fragments (1190, 983 and 207 bp) for genotype AB and undigested fragment (1190 ...

the association of rs10818488 snp located in traf1/c5 region with rheumatoid arthritis (ra), has been picked up by genome-wide association studies. independent studies in different populations revealed inconsistent results. the aim of this study was to investigate the possible association of this snp with ra in iranian population. a total of 362 cases and 422 healthy controls were recruited in ...

BACKGROUND CYP2E1 encodes an enzyme which is mainly involved in bioactivation of potential carcinogens such as N-nitrosamines. Polymorphisms in the gene have been reported to be associated with cancer. The aim of this study was to evaluate genotype distributions and allele frequencies of five CYP2E1 polymorphisms in Iran. MATERIALS AND METHOD Two hundred healthy individuals of an Iranian popu...

Results. The frequencies of TT genotype and T allele of CCL2-2518C/T gene polymorphism and CC genotype and C allele of VEGF-634G/C gene polymorphism were significantly high in HSP children (p-values = 0.005 and = 0.007 respectively). Interestingly, studying the joint interaction of these 2 genotypes (CC genotype of VEGF G-634C and TT genotype of CCL2 C-2518T) in this cohort showed a more signif...

In this study, the frequencies of CYP1A1, GSTM1, and GSTT1 gene polymorphisms were determined in 133 healthy individuals from Ouangolodougou, a small rural town situated in the north of the Ivory Coast. As appeared in several published studies, ethnic differences in these frequencies have been found to play an important role in the metabolism of a relevant number of human carcinogens. In the st...

Common alleles of the apolipoprotein-E gene (APOE) are associated with different risks of ischemic heart disease, Alzheimer's disease, and other chronic conditions in European populations. Also, the APOE allele frequencies vary widely among European countries. We estimated the proportion of differences in mortality and differences in life span that are attributable to differences in APOE allele...

background: the kiss peptins and its receptor g protein coupled receptor (gpr54) or kiss1 receptor system are being described as key signaling molecules for reproductive function in animal models and humans. they play essential roles in regulation of the hypothalamic- pituitary- gonadal (hpg) axis and the onset of puberty and fertility. objective: this study was performed to delineate the assoc...