Abstract Background : To investigate the associations of serum vitamin D and Fok I polymorphism its receptor (VDR) with unexplained recurrent spontaneous abortion (URSA). Methods Ninety URSA patients another 104 healthy pregnant women were selected as control groups, respectively. 25-Hydroxyvitamin [25-(OH)D] level was detected by chemiluminescence. VDR gene analyzed PCR, distribution genotype ...

BACKGROUND Knowledge on HBV prevalence and genotype distribution in Europe still is hampered by lack of coherent data sampling, small numbers of patients studied so far, and also modern times migration which influences both parameters in a quite dynamic manner. To find out whether HBV prevalence and genotype distribution has undergone any significant changes over the past decades, we have analy...

Emerging data suggest that the hepatitis B virus (HBV) genotype and the precore and core promoter variants impact the outcome of orthotopic liver transplantation (OLT) for hepatitis B. The aim of this study was to determine if there is a correlation between HBV genotype, precore and core promoter variants, and pre- and post-OLT outcomes. Serum samples from patients participating in the National...

Background: Host genetic variability has been suggested as an important explanation for inter-individual differences in COVID-19 susceptibility and severity. Most vitamin D actions the regulation of immunity are mediated by receptors (VDRs). Polymorphisms VDR gene have associated with several health outcomes; however, their effects on still need more clarification. This study aims to investigat...

Hepatitis B virus (HBV) infection is a critical global health issue and moderately epidemic in Western China, but HBV molecular epidemiology characteristics are still limited. We conducted this study to investigate HBV genotypes and antiviral resistant mutations in this multi-ethnic area. A total of 1316 HBV patients were recruited from four ethnic groups from 2011 to 2013. Genotypes and resist...

Over the last decade, CTX-M enzymes have become the most prevalent extended-spectrum beta-lactamases (ESBLs) worldwide, mostly in Escherichia coli, causing a major health problem. An epidemiological relationship has been established between a rare genotype of E. coli, the D(2) genotype, and the presence of CTX-M genes. We investigated this striking association by exploring the genetic backgroun...

Sudan is a highly endemic area for hepatitis B virus (HBV), and >5% of blood donors are chronically infected. To examine potential strategies to improve HBV blood safety, 404 replacement donor samples previously screened for HBV surface antigen (HBsAg) were tested for antibody to HBV core (anti-HBc), anti-surface antigen (anti-HBs), and HBV DNA. Of 145 anti-HBc-containing samples (36%) identifi...

Background The interaction between genetic, epigenetic and environmental factors plays an important role in the aetiology of hypertension. GWAS observational studies link C677T polymorphism methylenetetrahydrofolate reductase (MTHFR) with hypertension, while riboflavin, MTHFR cofactor, has been shown to reduce blood pressure global DNA methylation homozygous (TT genotype) individuals. It is cur...