BACKGROUND Insulin resistance is a frequent feature of chronic hepatitis C. Whether insulin resistance could be the cause or consequence of steatosis and fibrosis is unknown. The ability of HCV genotype 3 to promote steatosis by itself provides an unique opportunity to answer this question. AIMS The aim of the present study was to assess the relationships between insulin resistance, steatosis...

BACKGROUND Hepatitis C virus (HCV) genotype 6 is common among patients from Southeast Asia and the surrounding regions, where HCV prevalence is also high. HCV genotype 6 has great genetic diversity and different response to antiviral therapy compared with the more commonly known genotype 1. AIM Our goal was to provide a systematic review of the current literature on the epidemiology, classifi...

Hepatitis C virus (HCV) is classified into seven phylogenetically distinct genotypes, which are further subdivided into related subtypes. Accurate assignment of genotype/subtype is mandatory in the era of directly acting antivirals. Several molecular methods are available for HCV genotyping; however, a relevant number of samples with indeterminate, mixed, or unspecified subtype results, or even...

UNLABELLED Data show that viral genotype 1 may increase the risk of cirrhosis and hepatocellular carcinoma (HCC) compared to genotype 2 in patients with chronic hepatitis C virus (HCV) infection. However, the effect of HCV genotype 3 on cirrhosis and HCC risk is uncertain. We identified patients with active HCV infection, confirmed by positive polymerase chain reaction (PCR) and a known HCV gen...

OBJECTIVE To evaluate the distinct histopathological changes of chronic hepatitis C (CHC) non-responders in association with viral genotypes. METHODS This cross-sectional study was conducted at the histopathology section of the Dow Diagnostic Research and Reference Laboratory, Dow University of Health Sciences in collaboration with Sarwar Zuberi Liver Centre, Civil Hospital, Karachi from Sept...

This study described the structural characterization of Pakistani HCV NS3 GT3a in parallel with genotypes 1a and 1b NS3. We investigated the role of amino acids and their interaction patterns in different HCV genotypes by crystallographic modeling. Different softwares were used to study the interaction pattern, for example, CLCBIO sequence viewer, MODELLER, NMRCLUST, ERRAT score, and MODELLER. ...

To the Editor—Over the past few years, there has been substantial controversy regarding whether HIV-1/hepatitis C virus (HCV)–coinfected individuals experience more-rapid HIV-1 disease progression than do HIV-1–monoinfected individuals [1–3]. Yoo et al., in a cohort of largely untreated young HIV-1/HCV–coinfected participants with hemophilia who were followed for 7 years, observed lower CD4 + T...

Subjects and methods. The study included patients with IDC (group 1; n=111, 89.2% men, average age 51.7±9.7 years) ICM 2; n=110, 91.5% 58.7±8.4 years). All (IDC ICM) underwent coronary angiography. Based on the anamnesis data instrumental studies, those who could be said to have no risk factors for development of dilatation heart cavities were identified in group 1. And reliably diagnosed arter...