Genotoxic impurities can be broadly defined as those that have been demonstrated to cause harmful changes in genetic material regardless of the mechanism. Globally people suffer from various health complications due genotoxic impurities. Recent recommendations European and United States (USA) drug regulatory bodies mandate management possibly contaminants pharmaceutical ingredients at per milli...

Objective: Achyrocline satureioides “A.satureioides” is a subshrub, widely distributed in South America because of its medicinal properties. Although it used folk medicine, there still no approval for therapeutic use, and biocompatibility little explored. This study aimed to evaluate cytotoxicity genotoxicity over human gingival fibroblasts (FMM-1). Methodology: Ten different concentration the ...