Thank you for submitting your manuscript for consideration by the EMBO Journal. It has now been seen by two referees whose comments are shown below. We share the referees' interest in this manuscript, but also felt at the editorial level that the dataset could be developed realistically to allow more general as well as more mechanistically developed conclusions. I outline below key points raise...

Travel medicine becomes more important with the continual expansion of international travel and the increased popularity of exotic holiday destinations. In the United Kingdom general practitioners provide the bulk of travel health advice and immunisation and there is growing interest in providing these services. While their armamentarium has been expanded with attractive but expensive new vacci...

(The units can be presented as either single or double lectures) DNA origami pores DNA structure (primary, secondary, tertiary structure; A, B, Z-DNA; canonical and non-canonical base pairs, RNA vs DNA, Holiday and other multi-way junctions) DNA biochemistry (enzymatic synthesis, mechanism, replication fork, helicase) DNA chemistry (solid-phase synthesis, chemical modification at bases, nucleos...

BACKGROUND Recent findings suggest that patients admitted on the weekend with peptic ulcer bleeding might be at increased risk of adverse outcomes. However, other reports found that there was no "holiday effect." The purpose of this study was to determine if these findings hold true for a real-life Taiwanese medical gastroenterology practice. MATERIALS AND METHODS We reviewed the medical file...

Correspondence to Dr S Pal, Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK; [email protected] THE STORY A 57-year-old, right-handed housewife was admitted to a general medical ward in September 2005 after being found on the fl oor by a neighbour. She was unable to provide any indication as to what had happened. Her family reported cognitive ...