Considerable research eeort has been directed in recent years toward the problem of com-putationally identifying genes in DNA sequences. A fundamental component of a gene-nding system is a predictor which, when given a window of DNA sequence data, predicts whether or not it codes for protein product. In this paper we propose that mistake-driven, multiplicative-weight-update learning algorithms ...

When we work out the structure of DNA molecules, we examine the fundamental level that underlies all process in living cells. DNA is the information store that ultimately dictates the structure of every gene product, delineates every part of the organism. The order of the bases along DNA contains the complete set of instructions that make up the genetic inheritance. We do not know how to interp...

Urea plays various roles in the biology of diverse organisms. The past decade has produced new information on the molecular structure of several urea transporters in various species. Availability of DNA probes has revealed that the presence of urea transporters is not confined to the mammalian kidney but is also evident in testis and brain, raising new questions about the possible physiological...

Genes consist of multiple sequence elements that together encode the functional product and regulate its expression. Despite their fundamental importance, there are few freely available diagrams of gene structure. Presented here are two figures that summarise the different structures found in eukaryotic and prokaryotic genes. Common gene structural elements are colour-coded by their function in...

Ribosomal RNA (rRNA) genes, whose activity results in nucleolus formation, constitute an extremely important part of genome. Despite the extensive exploration into avian genomes, no complete description of avian rRNA gene primary structure has been offered so far. We publish a complete chicken rRNA gene cluster sequence here, including 5'ETS (1836 bp), 18S rRNA gene (1823 bp), ITS1 (2530 bp), 5...

Inferring the network structure of gene regulatory networks is one of the most important problems in contemporary bioinformatics. We analyze different methodologies for inferring small to very large sized gene networks. We use the datasets of DREAM 3 in-silico network challenge that is provided online [1]. The challenge involves inferring primarily the network structure from steady state gene e...

Homology-directed repair is a powerful mechanism for maintaining and altering genomic structure. We asked how chromatin structure contributes to the use of homologous sequences as donors for repair using the chicken B cell line DT40 as a model. In DT40, immunoglobulin genes undergo regulated sequence diversification by gene conversion templated by pseudogene donors. We found that the immunoglob...