Skeletal myogenesis depends on the strict regulation of the expression of various gene subsets. Therefore, the understanding of genome wide gene regulation is imperative for elucidation of skeletal myogenesis. In recent years, systems approach has contributed to the understanding of various biological processes. Our group recently revealed the critical genome network of skeletal myogenesis by u...

There are many immune mediated disorders with the corroborated role of vitamin D or Vitamin D Receptor (VDR) gene polymorphisms in their pathogenesis, immunologic regulation, and disease characteristics. Therefore, in this review, we searched PubMed data base in regard to the role of VDR gene polymorphisms in common autoimmune disorders, emphasizing on dermatologic diseases.

Sexual development has long been the target of study and despite great advances in our understanding of the composition and regulation of the gene network underlying gonadogenesis, our knowledge remains incomplete. Of particular interest is the relative role that the environment and the genome play in directing gonadal formation, especially the effect of environmental temperature in directing t...

Studies were done on analysis of biological processes in the same high expression (fold change ≥2) activated PTHLH feedback-mediated cell adhesion gene ontology (GO) network of human hepatocellular carcinoma (HCC) compared with the corresponding low expression activated GO network of no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection). Activated PTHLH feedback-mediated cell adhesion net...

In a recent issue of Molecular Cell, Kaplan et al. (2008) determine the input functions for 19 E. coli sugar-utilization genes by using a two-dimensional high-throughput approach. The resulting input-function map reveals that gene network regulation follows non-Boolean, and often nonmonotonic, logic.

We present a method for constructing electronic circuits that uses analogues of biological multi-cellular development, genetic regulatory networks, and transcription and translation processes to build circuits. We show how small circuits may be evolved and how they may be reused to build larger circuits. We also demonstrate that the artificial ‘organisms’ are capable of regeneration so that cir...

Between September Sh and September loth 1999 The First International Summer Scl~ool of Information Systems and Network Analysis of Gene Regulution and Metabolism was organized in Magdeburg. Post-genomic methods in molecular biology generate large amounts of expression data, which require computational methods for their storage, management, and analysis. Knowledge databases, containing informati...

This paper addresses the problem of identifying the large-scale topology of gene regulation networks from features that can be derived from microarray data sets. Understanding large-scale structures of gene regulation is fundamentally important in biology. Three main classes of network models, exponential network, scale-free network, and small-world network, have been used to describe topologic...