نتایج جستجو برای: gene expression il 1b
تعداد نتایج: 1705519 فیلتر نتایج به سال:
Hosoi, Toru, Yasunobu Okuma, and Yasuyuki Nomura. Electrical stimulation of afferent vagus nerve induces IL-1b expression in the brain and activates HPA axis. Am J Physiol Regulatory Integrative Comp Physiol 279: R141–R147, 2000.—Possible roles of the afferent vagus nerve in regulation of interleukin (IL)-1b expression in the brain and hypothalamic-pituitary-adrenal (HPA) axis were examined in ...
Glucose transporter 4 (GLUT4) is the major insulin-responsible glucose transporter expressed in muscle and adipose tissue and plays an important role in whole body glucose homeostasis. In the basal state, GLUT4 is sequestrated in several intracellular compartments, one of which has come to be known as insulin-responsive compartment (IRC). The IRC is a tissue specific compartment that is a targe...
When released into the bloodstream, proinflammatory cytokines have the ability to trigger the transcription of different genes in cells of the blood–brain barrier (BBB), including members of the nuclear factor kappa B (NF-kB) family and cyclooxygenase-2 (COX-2), the limiting enzyme for the formation of prostaglandins (PGs). The present study investigated the possibility that interleukin-1b (IL-...
Properties of thyme extracts from three different species (Thymus vulgaris, Thymus zygis, and Thymus hyemalis) were examined. Two oil fractions from each species were obtained by CO(2) supercritical fluid extraction. Main compounds presented in the supercritical extracts of the three thyme varieties were 1,8 cineole, thymol, camphor, borneol, and carvacrol. As a cellular model of inflammation/a...
Diabetes is associated with persistent inflammation and defective tissue repair responses. The hypothesis of this study was that interleukin (IL)-1b is part of a proinflammatory positive feedback loop that sustains a persistent proinflammatory wound macrophage phenotype that contributes to impaired healing in diabetes. Macrophages isolated from wounds in diabetic humans and mice exhibited a pro...
Background: Monosodium urate (MSU) has been shown to promote inflammasome activation and interleukin-1b (IL-1b) secretion in monocyte/macrophages, but the cellular pathway and nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in synovial tissues, remain elusive. In this study, we investigated the effects of MSU on synovial fibroblasts to elucidate the process o...
Background and purpose: HILA-G is an immunomodulatory molecule and alteration of its expression is prevalent during viral infections. HLA-G expression in HIV-positive patients has been inconsistent between different studies and some suggest that Interleukin-10 (IL-10) influences the expression of HLA-G. The aim of this research was to investigate the expression of IL-10 in HIV-positive patients...
Background: One of the important factors that play a key role in the pathogenesis of Alzheimer's disease (AD) is inflammatory processes leading to impaired expression of inflammatory cytokines such as interleukin-6, TNF-α, and interleukin-1β (IL-1β). Propolis, as a therapeutic compound, has anti-inflammatory and antioxidant properties. Therefore, the aim of the present study was to investigate ...
Alpha-lipoic acid (ALA) is a pleiotropic molecule with antioxidant and anti-inflammatory properties, of which the effects are exerted through the modulation of NF-kB. This nuclear factor, in fact, modulates different inflammatory cytokines, including IL-1b and IL-6, in different tissues and cell types. We recently showed that IL-1b and IL-6 DNA methylation is modulated in the brain of Alzheimer...
We have shown that interleukin-1b (IL-1b) activates the human brain natriuretic peptide (hBNP) promoter via a transcriptional mechanism. Others have reported that changes in intracellular calcium (Ca) mediate the action of IL-1b. We questioned whether Ca and Ca-dependent pathways mediate IL-1b regulation of the hBNP promoter in cardiac myocytes. The hBNP promoter (21818 to 1100) coupled to a lu...
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