The oral bioavailability of curcumin is limited, attributed to its low solubility or dissolution and poor absorption. Herein, the study describes formulation curcumin-loaded mixed micelles Gelucire® 48/16 TPGS for rate enhancement. Curcumin was dispersed in these molten lipidic surfactants which then adsorbed on carrier formulated as pellets by extrusion spheronization. Critical micelle concent...

Objective: Quercetin, a wonder flavanoid despite numerous pharmacological actions, has limited clinical applications due to solubility and permeability issues additionally having shorter biological half-life. The goal of the current work was design Quercetin lipid-based spherical crystals, improve its oral bioavailability sustain in vivo plasma levels. Methods: An anti-solvent precipitation met...

A differential many-multiplet (DMM) technique is developed to probe the variability of α. Applied to the Fe ii lines of the metal absorption line system at z abs = 1.839 in the spectrum of Q1101–264 obtained by means of the UV-Visual Echelle Spectrograph (UVES) at the ESO Very Large Telescope (VLT), the DMM provides ∆α/α = (2.4 ± 3.8stat) × 10 −6. The z abs = 1.15 Fe ii system toward HE0515–441...

Verification of theoretical predictions of an oscillating behavior of the fine-structure constant α (≡ e 2 /¯ hc) with cosmic time requires high precision ∆α/α measurements at individual redshifts, while in earlier studies the mean ∆α/α values averaged over wide redshift intervals were usually reported. This requirement can be met via the single ion differential α measurement (SIDAM) procedure ...

Detailed analysis of the spectral lines from two low redshift damped Lyman alpha absorbers (DLA) confirms that they are a heterogeneous population. Both systems have low metal abundances of approximately 0.05 to 0.1 solar. The abundance pattern of the DLA at z = 1.15 towards HE 0515-4414 shows dust depletion comparable to that found in our Galaxy, while the system at z = 0.68 towards HE 1122-16...