PURPOSE To investigate the role(s) of glial cell line-derived neurotrophic factor (GDNF) on expression of rod photoreceptor and dopaminergic amacrine cell-specific genes in an in vitro reaggregate model of the chick retina. METHODS Retinal reaggregates derived from embryonic day (E)6 chicks (rosetted spheroids) were supplemented with 50 ng/mL GDNF, or, alternatively, endogenous GDNF expressio...

Electrical stimulation (ES) of spiral ganglion cells (SGC) via a cochlear implant is the standard treatment for profound sensor neural hearing loss. However, loss of hair cells as the morphological correlate of sensor neural hearing loss leads to deafferentation and death of SGC. Although immediate treatment with ES or glial cell line-derived neurotrophic factor (GDNF) can prevent degeneration ...

Small-diameter sensory neurones found in the rat dorsal root ganglia (DRG) include cells sensitive to glial cell line-derived neurotrophic factor (GDNF), which express the inhibitory peptide somatostatin (SOM). Here we addressed the functional relationship between GDNF and sensory neurone-derived SOM. Topical application of GDNF through the rat isolated dorsal horn of the spinal cord promoted a...

, 163ra156 (2012); 4 Sci Transl Med et al. Mickael Decressac in Nigral Dopamine Neurons Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling − -Synuclein α Editor's Summary -synuclein toxicity and highlight Nurr1 as a promising new target for neuroprotective therapy. α against -synuclein toxicity. These results suggest that Nurr1 is a key player in the cellular defense α neurons subjected ...

Recent studies show that neuronal and glial plasticity are important for therapeutic action of antidepressants. We previously reported that antidepressants increase glial cell line-derived neurotrophic factor (GDNF) production in rat C6 glioma cells (C6 cells). Here, we found that amitriptyline, a tricyclic antidepressant, increased both GDNF mRNA expression and release, which were selectively ...

Mwangi SM, Usta Y, Raja SM, Anitha M, Chandrasekharan B, Parsadanian A, Sitaraman SV, Srinivasan S. Glial cell line-derived neurotrophic factor enhances neurogenin3 gene expression and -cell proliferation in the developing mouse pancreas. Am J Physiol Gastrointest Liver Physiol 299: G283–G292, 2010. First published May 6, 2010; doi:10.1152/ajpgi.00096.2010.—Glial cell line-derived neurotrophic ...

The formation of appropriate neuronal circuits is an essential part of nervous system development and relies heavily on the outgrowth of axons and dendrites and their guidance to their respective targets. This process is governed by a large array of molecules, including glial cell line-derived neurotrophic factor (GDNF) and the neural cell adhesion molecule (NCAM), the interaction of which indu...

This study investigated the effects of glial cell line-derived neurotrophic factor (GDNF) on dental pulp stromal cells (DPCs). Cultures of DPCs expressed GDNF as well as its receptors, GFR1 and RET. Addition of recombinant GDNF to cultures in serumcontaining medium did not significantly affect DPC growth; however, GNDF dosedependently increased viable cell number under serum-free culture condi...

There are several lines of evidence suggesting that, in addition to neurotrophins, member(s) of glial cell line-derived neurotrophic factor (GDNF) family play important roles in the development of sympathetic neurons. However, the mechanism regulating the responsiveness of the neurons to GDNF family members is not known. Previously, we reported on the cooperative roles of bone morphogenetic pro...

A major therapeutic target for Parkinson's disease (PD) is providing increased glial-derived neurotrophic factor (GDNF) to dopaminergic neurons. We tested the hypothesis that innate immune activation increases astrocyte GDNF production and that this is regulated by specific eicosanoid receptors. Innate immune-activated primary murine astrocytes were assayed for GDNF expression and secretion. Co...