Statins are the most commonly prescribed drugs in the United States and are extremely effective in reducing major cardiovascular events in the millions of Americans with hyperlipidemia. However, many patients (up to 25%) cannot tolerate or discontinue statin therapy due to statin-induced myopathy (SIM). Patients will continue to experience SIM at unacceptably high rates or experience unnecessar...

Mutations in the single-minded (sim) gene of Drosophila result in the loss of the precursor cells giving rise to the midline cells of the embryonic central nervous system. We have examined the structure of the sim product by sequencing a sim cDNA clone, and have also determined the subcellular localization of the protein and its developmental expression by staining embryos with an antiserum aga...

Development of the Drosophila CNS midline cells is dependent upon the function of the single-minded (sim) gene. Sequence analysis shows that sim is a member of the basic-helix-loop-helix class of transcription factors. Cell fate experiments establish that sim is required for early events in midline cell development, including a synchronized cell division, proper formation of nerve cell precurso...

We have investigated the roles of the single-minded (sim) and rhomboid (rho) genes in generating distinct cell fates in the Drosophila embryonic neuroectoderm. We show that sim functions to repress ventral ectodermal cell fates, as in sim mutants mesectodermal cells adopt the fates of neighboring ventral ectodermal cells and targeted sim expression in P[paired.Gal4]/P[UAS-sim] embryos results i...

BACKGROUND Basiliximab is a chimeric human/mouse monoclonal antibody directed against the alpha chain of the IL-2 receptor, CD25, which has been reported as successfully reducing rejection in adult renal transplant recipients. Reported clinical experience of basiliximab in paediatric renal transplantation is limited. METHODS Using two intravenous doses on day 0 (pre-operatively) and day 4 wit...

General circulation models (GCMs) are routinely used to simulate future climatic conditions. However, rainfall outputs from GCMs are highly uncertain in preserving temporal correlations, frequencies, and intensity distributions, which limits their direct application for downscaling and hydrological modeling studies. To address these limitations, raw outputs of GCMs or regional climate models ar...

5 In this paper, wintertime precipitation from a variety of observational datasets, 6 regional climate models (RCMs), and general circulation models (GCMs) is aver7 aged over the state of California (CA) and compared. Several averaging method8 ologies are considered and all are found to give similar values when model grid 9 spacing is less than 3◦. This suggests that CA is a reasonable size for...

a signed graph (marked graph) is an ordered pair $s=(g,sigma)$$(s=(g,mu))$, where $g=(v,e)$ is a graph called the underlyinggraph of $s$ and $sigma:erightarrow{+,-}$$(mu:vrightarrow{+,-})$ is a function. for a graph $g$, $v(g),e(g)$ and $c(g)$ denote its vertex set, edge set and cut-vertexset, respectively. the lict graph $l_{c}(g)$ of a graph $g=(v,e)$is defined as the graph having vertex set ...