Comparative genomics has revealed that variations in bacterial and archaeal genome DNA sequences cannot be explained by only neutral mutations. Virus resistance and plasmid distribution systems have resulted in changes in bacterial and archaeal genome sequences during evolution. The restriction-modification system, a virus resistance system, leads to avoidance of palindromic DNA sequences in ge...

We investigated the nucleotide composition of five genes, Xdh, Adh, Sod, Per, and 28SrRNA, in nine species of Drosophila (subgenus Sophophora) and one of Scaptodrosophila. The six species of the Drosophila saltans group markedly differ from the others in GC content and codon use bias. The GC content in the third codon position, and to a lesser extent in the first position and the introns, is hi...

Most transcriptional regulatory elements are located in non-coding DNA. In particular, some first introns play a vital role in transcriptional control and splicing. The length and GC-content of first exons and introns in complex organisms suggests that these structural units are likely to be important functional elements in large genomes. Hence, in this paper we perform a systematic comparison ...

So far, there is no genome-wide estimation of the mutational spectrum in humans. In this study, we systematically examined the directionality of the point mutations and maintenance of GC content in the human genome using approximately 1.8 million high-quality human single nucleotide polymorphisms and their ancestral sequences in chimpanzees. The frequency of C-->T (G-->A) changes was the highes...

Citation: Guerreiro TM, Ozawa KS, Lima EdO, Melo CFOR, de Oliveira DN, Triano SPdN and Catharino RR (2018) New Approach of QuEChERS and GC-MS Triple-Quadrupole for the Determination of Ethyl Carbamate Content in Brazilian cachaças. Front. Nutr. 5:21. doi: 10.3389/fnut.2018.00021 new approach of Quechers and gc-Ms Triple-Quadrupole for the Determination of ethyl carbamate content in Brazilian ca...

Species of the genus Staphylococcus have a guanine + cytosine (GC) content in DNA within the range 30.7-36.4 moles yo. All the Gram-positive cocci so far designated as micrococci and sarcinas which produce acid from glucose when grown under anaerobic or aerobic conditions and have a GC content in DNA within this range should be also classified as Staphylococcus. On the other hand species of the...

This study presents compelling evidence that recombination significantly increases the silent GC content of a genome in a selectively neutral manner, resulting in a highly significant positive correlation between recombination and "GC3s" in the yeast Saccharomyces cerevisiae. Neither selection nor mutation can explain this relationship. A highly significant GC-biased mismatch repair system is d...

In this paper, we construct linear codes over Z4 with bounded GCcontent. The codes are obtained using a greedy algorithm over Z4. Further, upper and lower bounds are derived for the maximum size of DNA codes of length n with constant GC-content w and edit distance d. keywords: DNA codes, GC-content, edit distance, upper and lower bounds.

This paper establishes that recombination drives the evolution of GC content in a significant way. Because the human P-arm pseudoautosomal region (PAR1) has been shown to have a high recombination rate, at least 20-fold more frequent than the genomic average of approximately 1 cM/Mb, this region provides an ideal system to study the role of recombination in the evolution of base composition. Ni...

Giemsa staining has been used for identifying individual human chromosomes. Giemsa-dark and -light bands generally are thought to correspond to GC-poor and GC-rich regions; however, several experiments showed that the correspondence is quite poor. To elucidate the precise relationship between GC content and Giemsa banding patterns, we developed an "in silico chromosome staining" method for reco...