BACKGROUND The prevalence of gastroesophageal reflux disease varies in different parts of the world. There are no population based studies in Nigeria. The main objectives of this study were to determine the prevalence and risk factors for gastroesophageal reflux disease in a population of Nigerian medical students. METHODS The Carlsson-Dent questionnaire was administered to medical students i...

PURPOSE Esophageal cancer is the seventh leading cause of cancer death worldwide and is responsible for 4% of the cancer deaths in the United States annually. Changing epidemiologic patterns and expanded treatment options have brought this often deadly cancer to the forefront. METHODS AND MATERIALS To characterize epidemiological changes, the effect of treatment advances, and patient outcomes...

Although the global incidence of gastric cancer has been decreased dramatically in recent decades, it is the most common cancer in north and northwest Iran. The wide variation in incidence across different geographical areas and higher proportion of cardia cancer are two main characteristics of gastric cancer in Iran. Current investigations indicate that a high prevalence of H.pylori infection,...

Gastroesophageal reflux disease (GERD) affects approximately 20% of the US population and is one of the most common acid-related disorders in US adults. One of the key symptoms of this often chronic disorder is heartburn. Gastroesophageal reflux disease is known to cause heartburn, and the presence of acid in the esophagus for prolonged periods is now known to place patients at risk for serious...

ERBB2-directed therapy is now a routine component of therapy for ERBB2-amplified metastatic gastroesophageal adenocarcinomas. However, there is little knowledge of the mechanisms by which these tumors develop acquired resistance to ERBB2 inhibition. To investigate this question we sought to characterize cell line models of ERBB2-amplified gastroesophageal adenocarcinoma with acquired resistance...

The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the distinction between adenocarcinomas above, below, or within the gastroesophageal junction; combined modality therapy; tumor markers for use in personalized medicine; PET-CT and endoscopic biopsies in the evaluation of response to neoadjuvant chemoradiation therapy; a standardized grading s...

Secondary achalasia due to submucosal invasion of cardia by gastric cancer is a rare condition. We report a case of pseudoachalasia, secondary to the involvement of gastroesophageal junction by poorly differentiated gastric cancer, initially mistaken as idiopathic form. We focus on the difficulty to establish differential diagnosis only on the basis of routine exams and we stress the necessity ...

BACKGROUND Gastroesophageal cancers, previously considered rare, are rapidly increasing worldwide. We present here a unique case of gastroesophageal carcinoma with metastasis to the rectum. CASE REPORT A 60-year-old female patient presented with constipation, bloating, and weight loss of 4-month duration. She had undergone sleeve gastrectomy 6 years before. Endoscopies performed revealed a fria...

background: sulfur mustard (sm) has acute and chronic effects on skin and mucosal surfaces. the aim of the study was to evaluate the frequency of esophagitis in a historical cohort of veterans who had been exposed to sm in iran-iraq war nearly 25 years ago.   methods : one hundred two veterans with dyspepsia and/or heartburn underwent esophago-gastro-duodenoscopy. of them, 52 cases had been exp...

BACKGROUND & AIMS A history of high body mass index (BMI) is associated strongly with a risk of esophageal adenocarcinoma (EAC). We investigated whether gastroesophageal reflux is involved in this association. METHODS We analyzed data from a population-based Swedish nationwide study of patients with a new diagnosis of EAC (n = 189) or gastroesophageal junction adenocarcinoma (n = 262), and ma...