BACKGROUND The clinical significance of weakly acidic reflux in infants is unclear. Skin conductance is a novel not-invasive method to evaluate discomfort. The aim of our study was to evaluate reflux-induced discomfort in infants with gastroesophageal reflux disease using simultaneously combined skin conductance and esophageal multichannel intraluminal impedance and pH monitoring. METHODOLOGY...

BACKGROUND Helicobacter pylori infection is less prevalent and atrophic gastritis is less extensive in patients with reflux oesophagitis than those without it, but few studies have examined this relationship directly. AIMS We investigated the relationship between H pylori infection, acid secretion, and reflux oesophagitis in Japanese subjects. SUBJECTS A total of 105 patients with erosive r...

BACKGROUND/AIMS The aim of this study is to investigate the reflux patterns in patients with galbladder stone and the change of reflux patterns after cholecystectomy in such patients. METHODS Fourteen patients with cholecystolithiasis and a control group including 10 healthy control subjects were enrolled in this prospective study. Demographical findings, reflux symptom score scale and 24-hou...

Nocturnal gastro-oesophageal reflux has been observed in patients with obstructive sleep apnoea (OSA). Negative intrathoracic pressure during apnoeas and arousal have been suggested as the underlying mechanisms. In order to evaluate this hypothesis, the coincidence and sequence in time of arousal, apnoea and reflux events were analysed. Fifteen patients with OSA or heavy snoring were studied by...

BACKGROUND AND AIMS Fatty foods are commonly reported to aggravate gastro-oesophageal reflux symptoms. In this study the hypothesis that fat provokes reflux by stimulating transient lower oesophageal sphincter relaxations via small intestinal receptors was investigated. METHODS In 12 healthy volunteers and 11 patients with reflux oesophagitis, oesophageal motility and pH were measured over 30...

introduction: gastroesophageal reflux (ger) is the most common esophageal disorder, which occurs at all ages. ger is defined as the passage of gastric contents into the esophagus. ger disease (gerd), which is a long-term complication, is a common pediatric problem. clinical manifestations of gerd in infants include regurgitation, irritability, choking, gagging, vomiting, poor weight gain, and r...

UNLABELLED Evidence of a relation between gastroesophaeal reflux and pediatric respiratory disorders increases every year. Many respiratory symptoms and clinical conditions such as stridor, chronic cough, and recurrent pneumonia and bronchitis appear to be related to gastroesophageal reflux. Some studies have also suggested that gastroesophageal reflux may be associated with recurrent laryngeal...

Vesico-ureteric reflux is commonly found in children who are investigated because of urinary tract infection. By allowing back-flow of infected urine from bladder into ureter, reflux may cause progressive damage to the upper urinary tract, such as dilatation of the ureter and scarring in the kidney. Hodson and Edwards (1960) noted that reflux was often associated with kidney scarring, and McGov...

BACKGROUND A widely used rat model for reflux-induced esophageal adenocarcinoma in the absence of carcinogens involves induction of duodenoesophageal reflux by performance of esophagoduodenostomy. The aim of this study was to test the hypothesis that acid reflux reduces the incidence of adenocarcinoma in this animal model. METHODS One hundred ninety 8-week-old male Sprague-Dawley rats were st...