نتایج جستجو برای: gamma release tests

تعداد نتایج: 658394  

2017
Haoran Zhang Xiangwei Li Henan Xin Hengjing Li Mufei Li Wei Lu Liqiong Bai Xinhua Wang Jianmin Liu Qi Jin Lei Gao

Body mass index (BMI) has been shown to be associated with host susceptibility to several infections. However, the link between BMI and the risk of tuberculosis (TB) infection has been sparsely studied in China and in worldwide. Based on the baseline survey of a population-based, prospective study in rural China, the association between BMI and TB infection among adults was estimated by means o...

Journal: :PLoS ONE 2008
Elizabeth Whittaker Andrea Gordon Beate Kampmann

BACKGROUND The blood based interferon-gamma release assays (IGRA) for the diagnosis of tuberculosis do not discriminate between active TB disease and latent TB infection (LTBI). The search for distinguishing biomarkers therefore continues, as the accurate diagnosis of tuberculosis is particularly challenging in children. IFN-gamma-inducible protein 10 (IP-10/CXCL10) has recently been evaluated ...

Journal: :PLoS ONE 2009
Martine G. Aabye Pernille Ravn George PrayGod Kidola Jeremiah Apolinary Mugomela Maria Jepsen Daniel Faurholt Nyagosya Range Henrik Friis John Changalucha Aase B. Andersen

BACKGROUND The performance of the tuberculosis specific Interferon Gamma Release Assays (IGRAs) has not been sufficiently documented in tuberculosis- and HIV-endemic settings. This study evaluated the sensitivity of the QuantiFERON TB-Gold In-Tube (QFT-IT) in patients with culture confirmed pulmonary tuberculosis (PTB) in a TB- and HIV-endemic population and the effect of HIV-infection and CD4 ...

2011

The Centers for Disease Control and Prevention recently published updated guidelines for the use of interferon gamma release assays (IGRAs) to detect Mycobacterium tuberculosis. This document gives a balanced analysis of the strengths and weaknesses of IGRAs. To date, these assays have not been widely adopted in the United States by clinical laboratories. We have asked two experts, Thomas Alexa...

2012
Chin-Chung Shu Vin-Cent Wu Feng-Jung Yang Sung-Ching Pan Tai-Shuan Lai Jann-Yuan Wang Jann-Tay Wang Li-Na Lee

BACKGROUND Tuberculosis is a common infectious disease in long-term dialysis patients. The prevalence of latent tuberculosis infection (LTBI) in this population is unclear, particularly in those receiving peritoneal dialysis (PD). This study investigated the prevalence of LTBI in patients receiving either hemodialysis (HD) or PD to determine predictors of LTBI and indeterminate results of inter...

Journal: :The Medical journal of Malaysia 2012
Y Swarna Nantha

A review of the epidemiology of tuberculosis, its contributing risk factors (excluding HIV) and the role of screening latent tuberculosis infection in Malaysia was done. Despite the global and domestic decrease in prevalence rates of tuberculosis in the past decade, there is an alarming increase in the trend of non communicable diseases in the country. High prevalence rates of major risk factor...

2016
Sarad PAUDEL Marvin A. VILLANUEVA Susan K. MIKOTA Chie NAKAJIMA Kamal P. GAIRHE Suraj SUBEDI Nabin RAYAMAJHI Mariko SASHIKA Michito SHIMOZURU Takashi MATSUBA Yasuhiko SUZUKI Toshio TSUBOTA

We developed an interferon-γ release assay (IGRA) specific for Asian elephants (Elephas maximus). Whole blood collected from forty captive Asian elephants was stimulated with three different mitogens i.e., phytohemagglutinin (PHA), pokweed mitogen (PWM) and phorbol myristate aceteate/ionomycin (PMA/I). A sandwich ELISA that was able to recognize the recombinant elephant interferon-γ (rEIFN-γ) a...

2013
Olivia Oxlade Marcia Pinto Anete Trajman Dick Menzies

INTRODUCTION Cost effectiveness analyses (CEA) can provide useful information on how to invest limited funds, however they are less useful if different analysis of the same intervention provide unclear or contradictory results. The objective of our study was to conduct a systematic review of methodologic aspects of CEA that evaluate Interferon Gamma Release Assays (IGRA) for the detection of La...

2016
Elissa Rennert-May Elisabeth Hansen Toktam Zadeh Valerie Krinke Stan Houston Ryan Cooper

Objectives. Approximately 65 percent of tuberculosis (TB) cases in Canada each year occur from reactivation in foreign-born individuals. Refugees are at high risk after immigration. Routine screening of this population for latent TB infection (LTBI) is generally considered infeasible. We evaluated the outcome of LTBI screening and treatment amongst refugees. Methods. Government-sponsored refuge...

Journal: :Chest 2012
Rahul Magazine

Correspondence TB is appropriate, particularly in high-prevalence countries. The study by Lee et al 2 performed in a high-prevalence Asian region and involving a very high number of untreated contacts demonstrates that the risk of progression is at its highest directly after Mycobacterium tuberculosis (MTB) infection and that more than one-half of those subjects who progressed to TB did so with...

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