We examined the mechanisms by which two different types of photonic radiation, short wavelength UV (UV-C) and gamma radiation, activate transcription factor NF-kappaB. Exposure of mammalian cells to either form of radiation resulted in induction with similar kinetics of NF-kappaB DNA binding activity, nuclear translocation of its p65(RelA) subunit, and degradation of the major NF-kappaB inhibit...

Background: Ionizing radiation causes deleterious effects on living system mainly due to oxidative damages of macromolecules and protein is the major target due to its abundance. The aim of this study was to investigate the effects of ionizing radiation induced changes in the molecular properties of bovine serum albumin (BSA) its secondary and tertiary structures, degradation, cross linking and...

Background: Protection of hematopoietic system has become a primary goal in the development of novel medical countermeasures against ionization radiation and radiotherapy. This study was to explore the role of rapamycin in normal tissues against radiation. Materials and Methods: Mice were pretreated with rapamycin by i.p. every other day for five times before 5 Gy or 8.5 Gy γ-ray whole bo...

background: currently available radioprotectors are poorly tolerated in man and the general use of aminothiols is compromised by their side effects. this study was carried out to test and compare the radioprotective potential of cimetidine and famotidine against lethally gamma irradiated nmri mice. materials and methods: adult male nmri mice in groups of 10 were exposed to various doses of gamm...

In the clinical setting, repeated exposures (10-30) to low-doses of ionizing radiation (≤200 cGy), as seen in radiotherapy for cancer, causes fatigue. Almost nothing is known, however, about the fatigue inducing effects of a single exposure to environmental low-dose ionizing radiation that might occur during high-altitude commercial air flight, a nuclear reactor accident or a solar particle eve...

EFFECTS OF THE GAMMA RADIATION IN NUTRITIONAL QUALITY OF SOYBEAN GRAINS Glycine max (L.) The objective of this study was to determine alterations caused by gamma radiation (doses of 0, 2, 4 and 8 kGy) in two different soybean cultivars (BRS 213 and Embrapa 48). The study included analysis of the lipid profi le, isofl avones and total, free and protein-binding polyphenols. Both cultivars showed ...

Six bacterial isolates from the U.S. DOE Subsurface Science Program and three reference bacteria were tested for resistance to UV light and gamma radiation. The subsurface isolates included three aerobic, pigmented, Gram positive bacteria and three microaerophilic, non-pigmented, Gram negative bacteria. Deinococcus radiodurans was the most resistant bacterium to both types of radiation, with a ...

Introduction The exposure of human beings to ionizing radiation from natural sources is a continuing and inescapable feature of life on earth. For most individuals, this exposure exceeds that from all man-made sources combined. Materials and Methods In this study, the annual effective dose in high level environmental background radiation areas (HLEBRAs) of northern city of Ramsar in Iran was de...

background: radioprotective effect of famotidine was previously shown on radiation induced micronuclei and chromosomal aberrations in human peripheral lymphocytes and mouse bone marrow cells however, its radioprotective property has never been studied in mouse spermatogenesis. it was also shown that vitamin c as an antioxidant also exert its radioprotective effect on many biological systems, bu...

BACKGROUND/AIMS Recent studies have shown that thymoquinone (TQ) exerts protective effects against ionizing radiation-induced cataracts in lens after total cranium irradiation of rats. Nevertheless, there is no published work investigated the effects of TQ on T cell development and biology in animal models exposed to gamma radiation. Therefore, in the present study we focused on determining the...