Chronic lymphocytic leukaemia (CLL) is the most common B-cell malignancy in the western world and exists as subtypes with very different clinical courses. Myeloid cell leukemia 1 (Mcl-1) is one member of Bcl-2 family proteins that has been shown to be expressed in various tissues and malignant cells, including CLL, where its expression is significantly associated with a failure to achieve compl...

α-Tocopheryl succinate (α-TS) and α-tocopheryloxyacetic acid (α-TEA) are potent inducers of apoptosis in cancer cells efficient suppressors tumors experimental model cell lines. They exhibit selective cytotoxicity against tumor very limited or no toxicity toward nonmalignant cells. In the present work, a series new α-tocopherol derivatives were synthesized as analogs α-TS α-TEA. The cytotoxic a...

introduction: apoptosis is an important mechanism in both physiological and pathological conditions. the bcl2 family of proteins plays a critical role in regulation of apoptotic cell death. up and down regulation of bcl2-like 12 (bcl2l12), a new member of the bcl2 family, has been reported in several malignancies. however, the expression level of bcl2l12 rarely has been studied in leukemia. thi...

Calpain is a calcium-dependent cysteine protease that is implicated in calcium-dependent cell death, and calpain inhibitors are generally considered as inhibitors of apoptosis. To the contrary, in the present study, we found that calpain inhibitor II (CPI-2) triggers rapid apoptosis in acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL) cells. All target cell lines were killed b...

B lymphoblastic leukemia (B-LL) is a clonal hematopoietic stem cell neoplasm derived from B-cell progenitors, which mainly occurs in children and adolescents one of the main causes death malignant tumors this population. The surface marker CD19 specifically expressed on membrane most B-cells, widely used as B-LL antigen-specific immunotherapy. In study, mesoporous titanium dioxide nanoparticles...

Discrete diagnostic subtypes of T lymphoblastic leukemia/lymphoma (T-cell acute lymphoblastic leukemia/lymphoma, T-ALL) have historically not been widely recognized. Recently, a novel subset with distinctive immunophenotypic, molecular, and clinical features has been proposed. Termed early T-cell precursor acute lymphoblastic leukemia (ETP-ALL), these cases seem to correspond to a very early st...

An efficient method for the synthesis of 3-(1H-indol-3-yl)-2-(7,8,12,13-tetraoxa-10-azaspiro[5.7]tridecan-10-yl)propanoic acid) via condensation 7,8,10,12,13-pentaoxaspiro[5.7]tridecane with tryptophan under action a catalyst based on Sm(NO3)3·6H2O has been developed. A high cytotoxic activity eight-membered azadiperoxide against tumor cells Jurkat, K562, U937, and HL60 was established. Additio...

Background: Natural products are characterized by a complex chemical composition and capable of concurrently modulate several signalling pathways. Considering the biological complexity carcinogenesis, natural represent key components therapeutic armamentarium for oncological diseases. The bark Terminalia arjuna is used in traditional Ayurvedic medicine its astringent, expectorant, cardiotonic, ...

A new compound, MK800-62F1, was isolated from a cultured broth of Streptomyces diastatochromogenes MK800-62F1. It inhibited H2O2-induced apoptosis in human small cell lung carcinoma Ms-1 cells as well as in human T-cell leukemia Jurkat cells. In addition, MK800-62F1 also inhibited camptothecin-induced apoptosis in Jurkat cells, which was mediated by intracellular H2O2 generation. MK800-62F1 did...

UNLABELLED Gene expression studies have consistently identified a HOXA-overexpressing cluster of T-cell acute lymphoblastic leukemias, but it is unclear whether these constitute a homogeneous clinical entity, and the biological consequences of HOXA overexpression have not been systematically examined. We characterized the biology and outcome of 55 HOXA-positive cases among 209 patients with adu...