ÐThe function of the cholinergic system is known to change during normal aging and in pathological conditions such as Alzheimer's disease. The present study was designed to assess, within the same group of old animals, the behavioral, electrophysiological and neurochemical effects of chronic treatment with agents that increase the function of the cholinergic system through both muscarinic and n...

In this study, Melaleuca alternifolia (Maiden and Betche) Cheel (tea tree) oil C. sinensis (L.) Osbeck (orange) was procured, their chemical compositions were characterized by gas chromatography coupled with mass spectrometry, co-injection using authentic samples. The oils rich in monoterpene hydrocarbons making up 84.5% of 48.9% M. oils. High amounts oxygenated monoterpenoids also identified (...

An increase in life expectancy creates prerequisites for the appearance of more patients with cognitive impairments. Early diagnosis, treatment and rehabilitation disorders improves quality patients, prevents development dementia, is great social importance. Herbal medicines are highly effective mild moderate impairment, affect various links pathogenesis, have minor side effects. The most them ...

BACKGROUND/AIMS A full comparison of the satisfaction with treatment using the current Alzheimer's disease (AD) therapies from the perspective of caregivers has not yet been done. The aim of this study was thus to find out the degree of satisfaction with the main available drug treatments in monotherapy for AD from this point of view. METHODS A cross-sectional, multicentre study of patients w...

The natural history of Alzheimer’s disease, combined with recognition of the advantages of introducing specific treatment early in the course of the disease, means that patients may take medication for several years. Previous studies of galantamine (Reminyl) have shown an excellent record of safety and efficacy over 12 months with a broad spectrum of benefits that includes functional and behavi...

BACKGROUND Cognitive deficits have been described in patients with schizophrenia from the first descriptions of dementia praecox to current concepts of cognitive dysmetria. Nevertheless, little is known about how to deal with them. In Alzheimer disease, cholinergic deficit is found and cholinesterase inhibitors have been used to delay the progression of memory and cognitive dysfunction. Several...

PURPOSE A clear correlation between vascular deficits and retinal ganglion cell (RGC) loss in glaucoma has not yet been established. The question arose as to whether there is loss of inner retinal vessels following intraocular pressure (IOP) increase and, if so, whether it occurs prior to, concomitantly with, or after RGC death. We also sought to establish whether galantamine, an acetylcholines...

Morcillo E. Changes in alpha-tocopherol and retinol levels during cardiopulmonary bypass correlate with maximal arterial partial pressure of oxygen. Free Radical Research. 2007;41:1061—7. 7. Centers for Disease Control and Prevention MMWR Morb Mortal Wkly Rep Editorial. Lactic acidosis traced to thiamine deficiency relate to nationwide shortage of multivita-min for parenteral nutrition. Respira...

INTRODUCTION in 2007 the National Institute of Health and Clinical Excellence (NICE) restricted the use of acetylcholinesterase inhibitors and memantine. METHODS we conducted a health technology assessment (HTA) of the effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of AD to re-consider and up-date the evidence base used to inform t...