We have previously found that the overexpression of p53 causes G2 arrest and represses the synthesis of cyclin-dependent kinase 1 and cyclin B1, two proteins required for cells to traverse from G2 into M. G2 arrest occurs in response to DNA damage caused by a variety of agents and treatments. Here, we investigate the role of p53 in the G2 arrest that occurs in response to the topoisomerase inhi...

The hypothesis tested is that a 24-h pre-irradiation-exposure of peripheral blood lymphocytes (PBL) to the benzene metabolite hydroquinone (HQ), at doses that are non-acutely toxic (5 microM), induces a less efficient G2-M-checkpoint and enhances the G2-chromosomal radiosensitivity in a statistically significant manner (p<0.01). A less efficient G2-M-checkpoint may allow the transition of damag...

We have characterized a murine IgG monoclonal antibody, OP-G2, specific for platelet glycoprotein (GP) IIb-IIIa (alpha IIb beta 3). OP-G2 Fab fragments inhibit fibrinogen-mediated platelet aggregation and competitively inhibit adenosine diphosphate-induced binding of 125I-fibrinogen to washed platelets. OP-G2 binding to GPIIb-IIIa is specifically inhibited by RGD-containing peptides but not the...

We investigate the effect of scale on performance in the active money management industry. We first document that fund returns, both before and after fees and expenses, decline with lagged fund size, even after accounting for various performance benchmarks. We then explore a number of potential explanations for this relationship. This association is most pronounced among funds that have to inve...

In this paper we consider pulsating strings in warped AdS 6 × S 4 background, which is a vacuum solution of massive type IIA super-string. The case of rotating strings in this background was considered in hep-th/0402202 and it was found that the results significantly differs from those considered in AdS 5 ×S 5. Motivated by this results we study pulsating strings in the warped spherical part of...

South China is a well-known grand felsic igneous rocks province. However, it still controversial and not well understood whether the Mesozoic tectono-magmatic pattern dominated by subduction of paleo-Pacific oceanic plate. In this study, we address question concentrating on long-term evolutionary Guandimiao batholith, which has complex lithofacies with different formation ages can be superb rec...

The group SU(3) is parameterized in terms of generalized “Euler angles”. The differential operators of SU(3) corresponding to the Lie Algebra elements are obtained, the invariant forms are found, the group invariant volume element is found, and some relevant comments about the geometry of the group manifold are made.

A predictive mathematical model of the transition from the G2 phase in the cell cycle to mitosis (M) was constructed from the known interactions of the proteins that are thought to play significant roles in the G2 to M transition as well as the DNA damage- induced G2 checkpoint. The model simulates the accumulation of active cyclin B1/Cdk1 (MPF) complexes in the nucleus to activate mitosis, the...

PURPOSE To describe the incidence of pregnancy associated hypertension and eclampsia from adolescence through the fifth decade of life, including the effect of parity and race, in the United States. METHODS Data were evaluated from the National Center for Health Statistics (vital statistics section). The data were stratified by maternal age group, parity (G1, first pregnancy; G2+, second or h...