Fragile X (FX) is the most common genetic cause of intellectual disability and autism. Previous studies have shown that partial inhibition of metabotropic glutamate receptor signaling is sufficient to correct behavioral phenotypes in a mouse model of FX, including audiogenic seizures, open-field hyperactivity and social behavior. These phenotypes model well the epilepsy (15%), hyperactivity (20...

In this chapter, the authors use an Agent-Based Modeling (ABM) approach to model trading behavior in the Foreign Exchange (FX) market. They establish statistical properties (stylized facts) of the traders’ trading behavior in the FX market using a high-frequency dataset of anonymised OANDA individual traders’ historical transactions on an account level spanning 2.25 years. Using the identified ...

The structure of factor X (FX) gene was analyzed in five FX deficient pedigrees with four different variants of the disease, as well as in 50 normal subjects. Genomic DNA from the deficient patients and the normal controls was digested with 12 restriction endonucleases and hybridized with a FX cDNA probe. The results seemingly exclude gross gene deletions or rearrangements in the deficient pati...

This paper proposes and discusses issues on local and global text structures, all of them being connected to a lexical concept of predication. The main contributions of the present work comprise: (a) A novel functional X-bar (FX-bar) scheme is advised, aiming to reveal, model and relate the local, clause-level markers and text structures. (b) At global level, two FX-bar schemes are proposed, on...

• For a discrete RV the mass function is pX(x) = P (X = x). The continuous analog is the probability density function (pdf) that may be interpreted as fX(x) ≈ P (x < X < x+ ∆)/∆ as 0 < ∆→ 0. • The cumulative distribution function (cdf) FX(x) = P (X ≤ x) is the probability that X is less than or equal to a specific value. In the continuous case we have fX(x) = dFX(x)/dx and FX(x) = ∫ x −∞ fX(r)d...

Fq = the finite field with q elements; throughout the paper q is assumed to be odd. A = Fq[T ], T indeterminate. F = Fq(T ) = the fraction field of A. |F | = the set of places of F . For x ∈ |F |, Fx = the completion of F at x. Ox = {z ∈ Fx | ordx(z) ≥ 0} = the ring of integers of Fx. Fx = the residue field of Ox; deg(x) = [Fx : Fq]. For 0 = f ∈ A, deg(f) = the degree of f as a polynomial in T ...

The need to simulate from a univariate density arises in several settings, particularly in Bayesian analysis. An especially efficient algorithm which can be used to sample from a univariate density, fX , is the adaptive accept-reject algorithm. To implement the adaptive accept-reject algorithm, the user has to envelope T ◦ fX , where T is some transformation such that the density g(x) ∝ T−1 (α ...

BackgroundIn all of randomized controlled trials mechanical thrombectomy, the target vessels were proximal. Herein we report a clinical trial Tron FX stent retriever, including smallest size 2/15 mm for distal intracranial large vessel occlusion (LVO).ObjectiveEligible patients presented within 8 h onset with proximal or LVOs, and 4/20 used as first-line device.MethodsThe primary endpoints rate...

Abstract Background and Aims Currently, there are calculation tools that predict the risk of fractures (fx), one which is Fracture Risk Assessment Tool (FRAX®). Patients with advanced chronic kidney disease (CKD) have a higher fx than general population it an independent factor for fx. However, this tool does not consider presence or absence CKD, where alterations in bone mineral metabolism imp...