Maglev is Google’s network load balancer. It is a large distributed software system that runs on commodity Linux servers. Unlike traditional hardware network load balancers, it does not require a specialized physical rack deployment, and its capacity can be easily adjusted by adding or removing servers. Network routers distribute packets evenly to the Maglev machines via Equal Cost Multipath (E...

The issue of heterozygosity continues to be a challenge in the analysis of genome sequences. In this article, we describe the use of allele ratios to distinguish biologically significant single-nucleotide variants from background noise. An application of this approach is the identification of lethal mutations in Caenorhabditis elegans essential genes, which must be maintained by the presence of...

To reduce the system bottle and improve the response speed of load banlancer, the factors influencing the load balancing are analyzed. Through the research on key technologies of current strategies and scheduling algorithms, a scheme for database deployment based on RAID technology is proposed. On the basis of our research, an extensible and centralized object-oriented load balancer is also put...

We studied the influence of soft-tissue releases and soft-tissue balance on the outcome of 526 total knee replacements one year after operation. The surgery had been performed by seven surgeons in five centres in the United Kingdom between October 1999 and December 2002. Balancing was carried out by five surgeons using spacers and trials and by two surgeons using a 'balancer' instrument. All th...

Now is the era of cloud computing and related buzzwords are the virtualization, resource sharing, Big Data. With the advent of new technologies, gadgets or simply IOT has enabled the advanced connectivity of devices, systems, and services and with this the data is being produced at an enormous rates from these devices be it form sensors, GPS data, log files from different sources etc. which is ...

Much population genetics and evolution theory depends on knowledge of genomic mutation rates and distributions of mutation effects for fitness, but most information comes from a few mutation accumulation experiments in Drosophila in which replicated chromosomes are sheltered from natural selection by a balancer chromosome. I show here that data from these experiments imply the existence of a la...

sFRP4 is an extracellular Wnt antagonist that fine-tunes its signal activity by direct binding to Wnts. Bone fragility under oxidative stress by diabetes and aging is partly related to the suppression of the Wnt signal through upregulated sFRP4. Here, to explore the functions of sFRP4 as a balancer molecule in bone development and remodeling, we analyzed the sFRP4 knock-in mouse strain. X-gal a...

The goal of a network load balancer is to distribute a workload evenly amongst a cluster of back-end servers. At present there are a number of standard request allocation schemes to distribute requests but none of these can guarantee an even load distribution. In order to improve the request allocation decisions made, I present an implementation of a dynamic feedback system as an extension for ...

[Purpose] The purpose of this study was to investigate how a stretching torque affects muscular contractures. [Subjects] The subjects of this study were 48 male Wistar rats. [Methods] Subjects were divided into 4 groups as follows: Group 1 was the control; Group 2 had muscles in continuous fixation; Group 3 had muscles stretched in the direction of dorsiflexion by a spring balancer set at a tor...