In the title compound, C(18)H(17)N(3)O(4), the amino group of the glycine methyl ester fragment is involved in an intra-molecular N-H⋯O hydrogen bond. The phenyl and furyl rings form dihedral angles of 10.20 (4) and 54.56°, respectively, with the pyrazole ring. In the crystal, mol-ecules related by translation along the b axis are linked into chains via weak inter-molecular C-H⋯O hydrogen bonds.

In the title mol-ecule, C(13)H(9)ClO(2), the benzene and furyl rings are slightly twisted from each other with a dihedral angle of 5.1 (1)°. An intra-molecular C-H⋯O hydrogen-bond inter-action generates an S(5) ring motif. In the crystal structure, mol-ecules are stacked along the b axis and the crystal packing is stabilized by weak inter-molecular C-H⋯O hydrogen bonds.

A series of new 2-(phenylthio) benzoylarylhydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, (1)H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv using the microplatealamar blu...

By the reaction of furan-2-carboxylic acids and furfural with diazonium salts 1a-j arylfuran-2-carboxylic 4a-e 5-arylfuran-2-carbaldehydes 5a-f were synthesized. Acids transformed into appropriated acylchlorides 6a-e used for preparation 4-(5-aryl-2-furoyl)morpholines 7a-e . 4-[(5-Aryl-2-furyl)carbonothioyl]morpholines 8a-f prepared from aldehydes by using Willgerodt-Kindler reaction. The struc...

The mol-ecule of the title Schiff base compound, C(14)H(13)N(3)O(2), is not perfectly planar; the furyl and pyridine rings are twisted with respect to each other along the C(4)N(2)C(2) organic chain, making a dihedral angle of 13.3 (1)°. The occurence of N-H⋯O hydrogen bonds builds up a chain developing parallel to the c axis.

Development of immunomodulatory agents that enhance innate immune responses represents a promising strategy for combating infectious diseases. In the present studies, we screened a series of 71 arylcarboxylic acid hydrazide derivatives for their ability to induce macrophage tumor necrosis factor alpha (TNF-alpha) production and identified six such compounds, including one compound previously sh...

A method for the synthesis of 1-(5-methyl-2-furoyl)thymine (7) and 1-(5-methyl-2-furyl)thymine (8) is described. Trimethylsilyliodide catalysed addition of 5-methyl-2,4-bis(trimethylsilyloxy)pyrimidine (9) to 2-methyl-2,5-dihydro-2,5-dimethoxyfuran yielded the new thymine derivative 13. Photooxidations of 7 and 8 gave not the expected addition products but furan endoperoxides and hydroperoxides...