It will be shown that the umbrella term “nanotechnology” reveals the endeavor of recent engineering sciences and science-based technologies to find a fundamental technology, in other words: a root or core technology. This is linked to the leading and exciting vision of a specific kind of reductionism, namely technological reductionism, which has not yet been perceived by the philosophy of scien...

Motivated by non-Poisson stochastic variability found in service system arrival data, we extend established service system staffing algorithms using the square-root staffing formula to allow for non-Poisson arrival processes. We develop a general model of the non-Poisson non-stationary arrival process that includes as a special case the non-stationary Cox process (a modification of a Poisson pr...

Orthopaedic surgery as a speciality lends itself well to tissue engineering. Many musculoskeletal tissues are frequently damaged or lost in injury and disease, and show a limited capacity for repair. Although orthopaedic surgery has been successful in replacing cartilage, the coming years will establish whether a shift from replacement towards regeneration of tissue is feasible. There has been ...

In designing a supply chain, firms are often faced with the competing demands of improved customer service and reduced cost. We develop a model that incorporates fixed distribution center location costs, working and safety stock inventory costs at the distribution centers, fixed and variable transport costs from a plant to the distribution centers and delivery costs to customers. Service is mea...