Malaria kills more than 1 million people a year, mostly children in sub-Saharan Africa. Antimalarial drug resistance is one of the greatest challenges facing malaria control today. We present Ronald, a Domain-Specific Language to model the fundamental forces driving antimalarial drug resistance including drug pharmacokinetics and pharmacodynamics, drug regimens and parasite genotypes. Example o...

HabilisDraw is a tool-based drawing environment that contains analogs of physical tools, such as pens, rulers, pushpins, and so forth. The environment is designed to exploit users’ intuitions about physical interactions between tools and objects. We are currently porting HabilisDraw to the DiamondTouch in order to explore issues in two-handed tool use.

Abstract. In this paper, we first derive specific results concerning the continuity and upper semi-continuity of the spectral radius and spectrum functions on fundamental locally multiplicative topological algebras. We continue our investigation by further determining the automatic continuity of linear mappings and homomorphisms in these algebras.

We investigate the relation between two quantitative measures characterizing short term memory in input driven dynamical systems, namely the short term memory capacity (MC) [2] and the Fisher memory curve (FMC) [1]. We show that under some assumptions, the two quantities can be interpreted as squared ‘Mahalanobis’ norms of images of the input vector under the system’s dynamics and that even tho...

Der folgende Artikel gibt einen Kurzüberblick über ein Promotionsvorhaben im Bereich der Quantitativen Modellierung. In der Dissertation soll die Modellierungsmethodik FMC-QE (Fundamental Modeling Concepts for Quantitative Evaluation) beschrieben werden. FMC-QE basiert auf der Modellierungssprache FMC sowie den Modellierungsund Berechnungsmethoden der Warteschlangentheorie und der Zeitbehaftete...

We consider on a two-dimensional flat torus T the following equation ∆u + ρ ( eu ∫ T e u − 1 |T | ) = 0. When the fundamental domain of the torus is (0, a) × (0, b) (a ≥ b), we establish that the constants are the unique solutions whenever ρ ≤ { 8π if b a ≥ π4 , 32 b a if b a ≤ π4 , and this result is sharp if b a ≥ π4 . A similar conclusion is obtained for general two-dimensional torus by cons...

Fixed–mobile convergence (FMC) is a radical innovation for telecommunication companies because it requires them to move into unknown territories that are beyond traditional business lines and underlying technologies. In the meantime, understanding what types of telecommunication companies are better at doing business through the early adoption of FMC has become increasingly important in the con...

the concept of causality is fundamental to our understanding of the world. the idea of causality was made popular, in western philosophy, by david hume; one of the best-know british empiricists. this paper examines critically the human idea of causality-that of a necessary/physical connection - in juxtaposition to an africa theory. the thesis that the causal relation, when correctly defined, is...

The differences between β- and γ-actin are deeper than those between the amino acid sequences of these two proteins.