Researchers have only recently begun using functional neuroimaging to explore the human response to periods of sustained anxious anticipation, namely potential threat. Here, we investigated brain responses acquired with functional MRI during an instructed threat of shock paradigm used to create sustained periods of aversive anticipation. In this re-analysis of previously published data, we empl...

Recent work suggests that our brains’ sub-structures change how they communicate with one another depending on the particular functions or computations that our ongoing cognitive processes demand (for review see [1]). The standard approach to estimating these so called functional connectivity patterns in functional magnetic resonance imaging (fMRI) data is to compute the correlation between the...

Brain connectivity analysis is a critical component of ongoing human connectome projects to decipher the healthy and diseased brain. Recent work has highlighted the power-law (multi-time scale) properties of brain signals; however, there remains a lack of methods to specifically quantify shortvs. longtime range brain connections. In this paper, using detrended partial cross-correlation analysis...

There is significant clinical and prognostic heterogeneity in the neurodegenerative disorder amyotrophic lateral sclerosis (ALS), despite a common immunohistological signature. Consistent extra-motor as well as motor cerebral, spinal anterior horn and distal neuromuscular junction pathology supports the notion of ALS a system failure. Establishing a disease biomarker is a priority but a simplis...