نتایج جستجو برای: fti
تعداد نتایج: 436 فیلتر نتایج به سال:
I have read the very interesting and informative article of Hoover et al,1 which may open new avenues in treating imatinib-refractory and imatinib-sensitive chronic myeloid leukemia (CML). However, when testing the synergic potential of STI farnesyl transferase inhibitor (FTI) combination on the STI571-sensitive Baf BCR-ABL-s cell line, a deficient statistical proof is shown. In their Figure 2A...
Elevated levels of mucins present in bronchiectatic airways predispose patients to bacterial infections and reduce the effectiveness of antibiotic therapies by directly inactivating antibiotics. Consequently, new antibiotics that are not inhibited by mucins are needed to treat chronic respiratory infections caused by Pseudomonas aeruginosa and Staphylococcus aureus. In these studies, we demonst...
File-type Identification (FTI) is an important problem in digital forensics, intrusion detection, and other related fields. Using stateof-the-art classification techniques to solve FTI problems has begun to receive research attention; however, general conclusions have not been reached due to the lack of thorough evaluations for method comparison. This paper presents a systematic investigation o...
Treatment of H-Ras transgenic mice with the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-2154 results not only in halting the growth of aggressive breast tumors but actually in inducing the regression (54 +/- 3%) of all 19 tumors analyzed. The farnesyltransferase (FTase) inhibitor FTI-2148 induced an average of 87 +/- 3% regression in the 13 tumors analyzed. GGTase I, but not FTase, is...
background: tibolone is frequently used as a hormone-like alternative to traditional hrt. therefore, it is valuable to compare the effects of tibolone and hrt on cardiovascular diseases risk factors. methods: a total of 156 healthy non-surgical postmenopausal women were included in an open randomized study. they were assigned to receive daily 2.5 mg tibolone plus one cal+d (500 mg calcium and...
Suppose (ftj)ist.jtr is a pxp matrix of real-valued infinitely (respectively /«-times continuously) differentiable functions on an open subset fl of R". Then (fti)isi,isp maps the space of ^-tuples of distributions on fl (respectively distributions of order Smonfi) into itself. In the present paper, the pxp matrices (P/)isi,<sp for which this mapping is onto are characterized in terms of the ze...
Many tumor cells have a greater resistance to ionizing radiation than their normal counterparts, suggesting that the development of drugs that can reduce that radioresistance would potentiate the efficacy of radiation therapy. Because activated H-ras expression has been shown to markedly increase radiation resistance in some transformed cells, the inactivation of H-ras would then be predicted t...
In high-performance computing, there is a perpetual hunt for performance and scalability. Supercomputers grow larger offering improved computational science throughput. Nevertheless, with an increase in the number of systems’ components and their interactions, the number of failures and the power consumption will increase rapidly. Energy and reliability are among the most challenging issues tha...
We assessed the clinical utility of measuring thyrotropin (TSH) in serum by immunoradiometry and of measuring total thyroxin (TT4), total triiodothyronine (TT3), free thyroxin (FT4), and free triiodothyronine (FT3). We used a group of 110 healthy volunteers, 45 ill hypoalbuminemic patients, and 42 ill normoalbuminemic patients. In addition, the free thyroxin index (FTI) and TT4:thyroxin-binding...
به منظور بررسی اثر سن ، جنس ، آبستنی و شیرواری بر غلظت سرمی هورمونهای غده تیروئید بزهای ایرانی ، نمونه های خون 102 رأس بز ایرانی در سنین مختلف ( کوچکتر از 1، 2-1 ، 3-2، 4-3، 5-4 و بزرگتر از 5 سال ) ، دو جنی نر و ماده و وضعیتهای آبستن و غیر آبستن و شیروار و غیر شیروار تهیه شدند . در سرم بزهای مورد مطالعه ، غلظت تیروکسین (t4)، تری یدوتیرونین (t3)، t3 uptake و شاخص تیروکسین آزاد (fti) مورد سنجش قر...
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