Objective: The present study aims to prepare stains-loaded enteric-coated pellets by extrusion and spheronization technique for acidic environment protection improve the viability of strains during storage. Methods: Lactobacillus casei plantarum are proven have various therapeutic prophylactic uses in human beings, but low stability storage transit site action has limited their action. Pellets ...

Three-dimensional (3D) printing is a recent technology, which gives the possibility to manufacture personalised dosage forms and it has broad range of applications. One most developed, oral solid four 3DP techniques have been more used for their are FDM, inkjet 3DP, SLA SLS. This systematic review carried out statistically analyze current employed in manufacturing formulations assess trends thi...

common variable immunodeficiency (cvid) is a primary immunodeficiency disease characterized by hypogammaglobulinemia and recurrent bacterial infections especially in respiratory and gastrointestinal systems. we present here 2 cases of cvid with gastrointestinal complications. case 1 is a 25-year-old man with a history of chronic diarrhoea from childhood. ultrasonography revealed ascites, with l...

In the present research work mouth dissolving tablets of domperidone were developed with superdisintegrants like crospovidone, croscarmellose sodium and sodium starch glycollate in various concentrations like 3%, 4% and 6% w/w by direct compression method. All formulations were evaluated for physical characteristics of compressed tablets such as weight variation, hardness, friability, content u...

The object of the study was to formulate and evaluate Aceclofenac orodispersible tablets (ODT) by wet granulation method using different super disintegrants in different concentrations. Orodispersible tablets produce rapid dissolution of drug and absorption thereby producing rapid onset of action. Five batches (AFD1, AFD2, AFD3, AFD4, AFD5) of Aceclofenac orodispersible tablets were prepared an...

This study evaluates the disintegrant properties--tablet disintegration time (DT) and crushing strength--friability/disintegration time (CSFR/DT) ratio of a paracetamol tablet formulation prepared with sorghum and plantain starches in comparison with corn starch BP. The effects of disintegrant concentration, relative density of tablets and the mode of disintegrants addition were studied. The st...

In the present study, fast disintegrating tablets were designed with a view to enhance patient compliance. In this method, the hull of Hordeum vulgare, cross carmellose sodium, and sodium starch glycolate were used as superdisintegrants (4 and 6%), along with microcrystalline cellulose and mannitol, to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, ...

A refmpective study of ten patients with myxomatous degeneration of cardiac valves revealed two patients with "floppy valve syndromen and eight patients with isolated myxomatous change of apparently diverse etiology. The myxomatous degeneration can be seen in a minor degree in normal valves and to a greater extent in clinical and experimental diseases of unknown etiology. The dBicnlties encormt...

A novel liquisolid compact technique was used for soulbility enahncement of poorly water soluble drug carvedilol (CAR). CAR was dissolved in water miscible non volatile solvent and then adsorbed on a solid carrier which was later compacted with other excipient into a tablet. The tablets were characterized with respect to hardness, friability, disintegration and in-vitro dissolution profile. Eff...

Sustained release tablets of Rosuvastatin were developed to prolong r e l e a s e o f time leading to an increase in drug bioavailability.Tablets are prepared by direct compression technique using polymers HPMC K15M,HPMC K50M and ethylcellulose.Tablets were evaluated for their physical characteristics viz.,hardness, thickness, friability and weight variation, drug content and floating propertie...