Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Several studies have shown that ALL occurs as a result of genetic abnormalities. 1, 25-Dihydroxyvitamin D3 as a secosteroid hormone plays an important role in different metabolic pathways. The normal function of vitamin D occurs via binding to a ligand-activated transcription factor i.e. vitamin D receptor (VDR)...

BACKGROUND AND AIM To identify the geographic distribution of hepatitis C virus (HCV) genotypes and HCV RNA viral load in a large number of HCV-infected carriers in Mexico. METHODS Patients with chronic hepatitis C (n = 8,802) were studied to identify HCV genotype using an immune line probe assay in samples shown previously to be positive for viral RNA by an RT-PCR test. Baseline HCV RNA was ...

  Objective(s): Apolipoprotein E genotype (APOE) polymorphism affects lipid levels and coronary artery disease (CAD) risk. The aim of this study was to study the association of the Apolipoprotein E genotypes with coronary artery disease in the Iranian population.   Materials and Methods: The Apolipoprotein E genotype in DNA samples extracted from 66 CAD+ patients and 61 control s...

introduction: caveolin-1 (cav-1) is a scaffolding protein found in special structures of plasma membrane, known as caveolae. cav-1 can regulate many intracellular processes, including signal transmission and cholesterol metabolism. this protein plays an important role in the growth and differentiation of breast tissue and acts as a tumor suppressor gene as well. the aim of this study was to det...

  Purpose: Estrogen as a crucial hormone during pregnancy acts by two types of receptors.   Estrogen receptor alpha, expressed by estrogen receptor 1 (ESR1) gene, is more abundant and   exists in all human reproductive systems. Association of ESR1 gene polymorphism has been   shown in some reproductive fields such as spontaneous abortion, endometriosis-related infertility   and in vitro fertili...

conclusions our results showed that hcv genotype 4 is the most prevalent genotype in the middle east region. however, hcv genotype 1 is the most prevalent among non-arab countries in the region including turkey, iran, cyprus, and israel. context the hepatitis c virus (hcv) is classified into seven genotypes and more than 100 subtypes. the treatment regimen, duration and efficacy of hcv therapy ...

in order to explore the nature of glucose-6-phosphate dehydrogenase (g6pd) deficiency in one of the coastal provinces of the caspian sea (mazandaran) in iran, we have analysed the g6pd gene in 74 unrelated g6pd-deficient males (2-6 year children) with a history of favism, by using pcr and subsequent digestion by appropriate restriction enzymes, looking for the presence of certain known mutation...