background: clofibrate is a pharmacological agent, which affects the lipid metabolism. this compound could be involved in bilirubin accumulation and excretion process. therefore, this study aimed to evaluate the effect of oral clofibrate intake on total serum bilirubin (tsb) of neonates hospitalized at khatam hospital. methods: this clinical trial was conducted on 73 neonates with hyperbilirubi...

Stokes identified the phenomenon of fluorescence in the mid 19 century, and the first fluorescence microscopes were developed at the beginning of the 20th Century. These were used to study autofluorescence in organic and inorganic compounds. Imaging of secondary fluorescence (whereby specific tissues and bacteria which did not autofluoresce were labeled with a fluorescent marker and subsequentl...

Introduction:The aim of this study is to compare significant post-phototherapy bilirubin rebound in two groups of neonates, with two levels of bilirubin, at discontinuation of phototherapy. Materials and Methods:One hundred and fifteen neonates ≥35 weeks of gestationl age (GA), admitted due to hyperbilirubinemia in the Neonatal Ward of Valiasr Hospital, were randomly divided into two groups: gr...

Background: Bilirubin encephalopathy is a clinical syndrome, associated with bilirubin toxicity in the central nervous system, resulting in chronic and permanent sequelae. It has been estimated that approximately 60% and 80% of term and preterm newborns develop jaundice in the first week of life, respectively. In the present study, we aimed to determine the prevalence, morbidity, and mortality ...

In this work, we verified that transferrin fluorescently labelled with lissamine rhodamine sulfochloride (Tf-LRSC) is internalized in epidermoid A431 carcinoma cells through the specific endocytic pathway of transferrin. The FRAP of this fluorescent marker internalized in the late compartment of transferrin endocytosis (LCT) was measured in living A431 cells. These experiments showed the presen...

Background: Hyperbilirubinemia is a common and usually a benign problem of neonates that affect on 80% immature and 60% term of them. Oral administration of nonabsorbable substances that bind to bilirubin in the intestinal lumen and reduce enteric absorption of bilirubin may reduce peak serum bilirubin. Activated charcoal, agar and cholestramin have been used but further study of this type of t...