نتایج جستجو برای: fra interpretation
تعداد نتایج: 152263 فیلتر نتایج به سال:
Cardiac hypertrophic stimuli induce both adaptive and maladaptive growth response pathways in heart. Here we show that mice lacking junD develop less adaptive hypertrophy in heart after mechanical pressure overload, while cardiomyocyte-specific expression of junD in mice results in spontaneous ventricular dilation and decreased contractility. In contrast, fra-1 conditional knock-out mice have a...
BACKGROUND Microvascular damage is one of the first pathological changes in systemic sclerosis. In this study, we investigated the role of Fos-related antigen-2 (Fra-2), a transcription factor of the activator protein-1 family, in the peripheral vasculopathy of systemic sclerosis and examined the underlying mechanisms. METHODS AND RESULTS Expression of Fra-2 protein was significantly increase...
BACKGROUND Previous studies demonstrated a functional involvement of the AP-1 transcription factor in HPV-induced cervical carcinogenesis. Here, we aimed to obtain further insight in expression alterations of AP-1 family members during HPV-mediated transformation and their relationship to potential regulatory (Notch1, Net) and target (CADM1) genes. METHODS mRNA expression levels of c-Jun, Jun...
To understand the mechanisms by which thrombin induces vascular smooth muscle cell (VSMC) DNA synthesis and motility, we have studied the role of phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR)-S6K1 signaling. Thrombin stimulated the phosphorylation of Akt and S6K1 in VSMC in a sustained manner. Blockade of PI3K-Akt-mTOR-S6K1 signaling by LY-294002, and rapamycin s...
Road freight transportation between provinces of a country has an important effect on the traffic flow of intercity transportation networks. Therefore, an accurate estimation of the road freight transportation for provinces of a country is so crucial to improve the rural traffic operation in a largescale management. Accordingly, the focused case study database in this research is the informatio...
The effects of the pumping wavelength and their power on the gain flattening of a fiber Raman amplifier (FRA) are investigated. The multi-wavelength pumping scheme is utilized to achieve gain flatness in FRA. It is proposed that gain flatness becomes better with increase in number of pumping wavelengths applied. We have achieved flat gain with 0.27 dB fluctuation in a spectral range of 1475-160...
Fragile (X)(q27) sites in a pedigree with female carriers showing mild to severe mental retardation.
A pedigree showing the fragile site at Xq27 in a severely retarded female and in other less retarded carriers is described. Two of the four moderately retarded males with the fra(X)(q27) show macro-orchidism, and a variety of other features usually used to support the effects of the fra(X)(q27) are also inconsistent. A second fragile site at (10)(q23) is also present and in the two oldest femal...
Frequency Response Analysis (FRA) technique has been recognized by worldwide utilities as a matured technology to assess the mechanical integrity of power transformers. While some industrial critical assets such induction motors have same construction principle transformers, application FRA not yet fully explored. This paper presents analogical experimental studies for on transformers and motor...
Background Folate Receptor Alpha (FRa) is an immunogenic protein that is over-expressed in breast, endometrial and ovarian cancer (OC). In fact, FRa expression in malignant cells is 20-fold higher compared to normal cells. We have begun a phase 1 clinical trial with E39, an HLA-A2 restricted, FRa peptide vaccine. The vaccine is administered in the adjuvant setting to prevent recurrences in high...
FAST MULTIPLICATION AND ITS APPLICATIONS DANIEL J. BERNSTEIN Abstra t. This survey explains how some useful arithmeti operations an be sped up from quadrati time to essentially linear time. x2. Produ t: the FFT ase x13. Sum of fra tions x3. Produ t: extension x11. Matrix produ t x14. Fra tion from ontinued fra tion x4. Produ t: zero-padding and lo alization 55 k k k k k k k k k k k k k x12. Pro...
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