نتایج جستجو برای: fra evaluation methods

تعداد نتایج: 2519084  

Journal: :Preventive medicine 1999
K Shirasaya M Miyakawa K Yoshida E Takahashi N Shimada T Kondo

BACKGROUND the optimal indicator for screening for diabetes mellitus without relying on fasting conditions was clarified. METHODS the subjects were 891 men ages 26 through 80 years (48.5 +/- 8.5). The objectives of this study were (1) to elucidate the efficacy of 1,5-anhydroglucitol (1,5-AG), glycosylated hemoglobin, and fructosamine (FRA) as screening tests for non-insulin-dependent diabetes...

Journal: :Molecular and cellular biology 2004
Peter M Burch Ziqiang Yuan Anne Loonen Nicholas H Heintz

Mitogens activate cell signaling and gene expression cascades that culminate in expression of cyclin D1 during the G(0)-to-G(1) transition of the cell cycle. Using cell cycle arrest in response to oxidative stress, we have delineated a dynamic program of chromatin trafficking of c-Fos and Fra-1 required for cyclin D1 expression during cell cycle reentry. In serum-stimulated lung epithelial cell...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2008
Robert Eferl Peter Hasselblatt Martina Rath Helmut Popper Rainer Zenz Vukoslav Komnenovic Maria-Helena Idarraga Lukas Kenner Erwin F Wagner

Studies using genetically modified mice have revealed fundamental functions of the transcription factor Fos/AP-1 in bone biology, inflammation, and cancer. However, the biological role of the Fos-related protein Fra-2 is not well defined in vivo. Here we report an unexpected profibrogenic function of Fra-2 in transgenic mice, in which ectopic expression of Fra-2 in various organs resulted in ge...

Journal: :Molecules 2017
Lukáš Slovák Karol Švík Danica Mihalová Jaroslav Tóth Szilvia Czigle Ľudmila Pašková František Bilka Katarína Bauerová

Methotrexate (MTX) is still the gold standard for treatment of rheumatoid arthritis (RA). The therapeutic efficacy of low-dose of MTX can be increased by its combination with a natural substance, ferulaldehyde (FRA). The aim of this study was to evaluate the effect FRA and MTX administered alone or in combination in adjuvant arthritis. The disease was induced to Lewis male rats by intradermal i...

Journal: :Endocrinology 2001
L K McCauley A J Koh-Paige H Chen C Chen C Ontiveros R Irwin L R McCabe

PTH and PTH-related protein (PTHrP) are key mediators of skeletal development and homeostasis through their activation of the PTH-1 receptor. Previous studies have found that several AP-1 family members are regulated by PTH, such as c-fos, fra-1, and c-jun. There are numerous genes in the bone microenvironment that contain AP-1 sites, and different Fos family members are reported to have opposi...

2012
Christian Seutter von Loetzen Kristian Schweimer Wilfried Schwab Paul Rösch Olivia Hartl-Spiegelhauer

The PR10 family protein Fra a 1E from strawberry (Fragaria x ananassa) is down-regulated in white strawberry mutants, and transient RNAi (RNA interference)-mediated silencing experiments confirmed that Fra a 1 is involved in fruit pigment synthesis. In the present study, we determined the solution structure of Fra a 1E. The protein fold is identical with that of other members of the PR10 protei...

Journal: :Cortex; a journal devoted to the study of the nervous system and behavior 2003
Jonathan J Evans Kim S Graham Katherine H Pratt John R Hodges

We report a long-term follow-up study of case JM, who demonstrated a focal retrograde amnesia (FRA) as a consequence of cerebral vasculitis. The present study showed that, several years post-onset, JM experienced considerable impairment in episodic retrograde memory, with normal anterograde autobiographical memory. Further investigations demonstrated that she showed no evidence of accelerated f...

2006
Daniel Rairigh Andrew Mason Chao Yang

Despite the great number of exciting applications for chip-scale, impedance-based sensor arrays, almost no on-chip instrumentation circuitry exists to support such systems. This void is inhibiting further research with many nanotechnology sensors and impeding the full potential of many related applications. This paper outlines the key requirements for instrumentation circuitry to measure the co...

Journal: :Genes & development 2005
Romeo Ricci Urs Eriksson Gavin Y Oudit Robert Eferl Alexander Akhmedov Izabela Sumara Grzegorz Sumara Zamaneh Kassiri Jean-Pierre David Latifa Bakiri Bernd Sasse Maria-Helena Idarraga Martina Rath David Kurz Hans-Christian Theussl Jean-Claude Perriard Peter Backx Josef M Penninger Erwin F Wagner

Cardiac hypertrophic stimuli induce both adaptive and maladaptive growth response pathways in heart. Here we show that mice lacking junD develop less adaptive hypertrophy in heart after mechanical pressure overload, while cardiomyocyte-specific expression of junD in mice results in spontaneous ventricular dilation and decreased contractility. In contrast, fra-1 conditional knock-out mice have a...

Journal: :American journal of physiology. Cell physiology 2006
Huiqing Cao Nagadhara Dronadula Gadiparthi N Rao

To understand the mechanisms by which thrombin induces vascular smooth muscle cell (VSMC) DNA synthesis and motility, we have studied the role of phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR)-S6K1 signaling. Thrombin stimulated the phosphorylation of Akt and S6K1 in VSMC in a sustained manner. Blockade of PI3K-Akt-mTOR-S6K1 signaling by LY-294002, and rapamycin s...

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