A persuasive link between hemostatic factors and cancer has been developed through extensive studies of both human and animal malignancies. Coagulation-, plateletand fibrinolytic-factors all have been tightly associated with tumor growth and/or dissemination. Nevertheless, the mechanisms by which these factors influence tumor growth and progression remain to be fully defined. Recent studies of ...

To identify the most active curative treatment of Buruli ulcer, two regimens incorporating the use of rifampin (RIF) were compared with the use of RIF alone in a mouse footpad model of Mycobacterium ulcerans infection. Treatments began after footpad swelling from infection and continued for 12 weeks with five doses weekly of one of the following regimens: (i) 10 mg of RIF/kg alone; (ii) 10 mg o...

Only native products of Mycobacterium leprae, whether cell wall, cytosol, or membrane derived, can confer protective immunity against challenge in the mouse footpad. Previously, recombinant proteins were shown to be ineffective. The cell wall skeleton-the mycolyl-arabinogalactan-peptidoglycan complex-devoid of proteins is not protective.

As measured by a proportional bactericidal technique in the mouse footpad system, the bactericidal activity against Mycobacterium leprae of R207910 was equal to that of rifapentine, rifampin, or moxifloxacin and significantly greater than those of minocycline, PA-824, and linezolid. These data suggest that R207910 may play an important role in treatment of leprosy.

Footpad infection of guinea pigs with herpes simplex virus led to an acute local inflammatory reaction, followed by a persistent latent infection of lumbosacral dorsal root ganglia. Spontaneous reactivation of the latent virus occurred, leading to recurrent lesions at the site of the initial infection. Clinical observations and virological studies during the acute latent and recurrent infection...

Methods. Bovine Py was expressed in Escherichia coli cells and purified by fast protein liquid chromatography. Lewis rats were immunized by a single footpad injection of Py emulsified in complete Freund's adjuvant. Clinical and histopathologic changes in the eye and pineal gland were examined. Lymphocytes were prepared from the lymph nodes of rats with uveitis and transferred by intraperitoneal...

Infection of mice with Pseudomonas aeruginosa, washed and unwashed, mucoid and nonmucoid, altered subsequent immunity to Listeria monocytogenes. Mice were protected against lethal doses of L. monocytogenes yet exhibited decreased delayed-type hypersensitivity footpad swelling to sublethal doses. The mucoid coating of mucoid P. aeruginosa, an important pathogen in chronic bronchopulmonary disord...

www.sciencemag.org SCIENCE VOL 325 3 JULY 2009 5 COVER The Phoenix spacecraft on the martian polar plains (68°N latitude). The footpad at the bottom is about 1 meter below the spacecraft deck seen at the lower left. Overlaid images are trenches dug to either nearly pure water ice or ice-cemented soil. Analyses of samples taken from these trenches give clues to the history of the region. Results...