Serial tissue culture passaging of three foot-and-mouth disease temperature-sensitive mutants demonstrated the stability of their temperature sensitivity and mouse avirulence characteristics. Recovery of mouse-virulent temperature-sensitive viruses after passage of the mutants in mice suggested that these were not covariant expressions of the same locus, but were under the control of different ...

Since 2001 models of the spread of foot-and-mouth disease, supported by the data from the UK epidemic, have been expounded as some of the best examples of problem-driven epidemic models. These claims are generally based on a comparison between model results and epidemic data at fairly coarse spatio-temporal resolution. Here, we focus on a comparison between model and data at the individual farm...

Information with regard to foot-and-mouth disease (FMD) outbreaks that occurred in the Kruger National Park (KNP) and adjacent areas of South Africa between 1970 and 2009 was collected from reports and files of various government departments and collated into one report. The collected data were summarised in a table and assessed for patterns. Fifty-one FMD outbreaks occurred during this period ...

The authors describe a questionnaire survey of foot and mouth disease (FMD) and of FMD control by vaccination in sixty villages in northern Thailand. FMD was found to be common, with 90% of the villages surveyed reporting one or more outbreaks in the five years prior to interview, and 28% of villages reporting outbreaks every year. Outbreaks were more common in the wet season (June to September...

The complete genome of a foot-and-mouth disease type O virus originating from an epidemic in Greece in 1994 is reported. This virus belongs to the Middle East-South Asia topotype.

Foot-and-mouth disease virus (FMDV) exists as multiple serotypes and strains that infect a range of cloven-hoofed animals with variable severity. Clinical diagnosis reinforced by diagnostic tests support timely intervention, whilst virus characterisation helps trace routes of spread and select appropriate vaccine strains. To speed up and simplify diagnosis, penside tests have recently been deve...