نتایج جستجو برای: fold combinations
تعداد نتایج: 219280 فیلتر نتایج به سال:
Recent research shows that a faulty or sub-optimally operating metabolic network can often be rescued by the targeted removal of enzyme-coding genes - the exact opposite of what traditional gene therapy would suggest. Predictions go as far as to assert that certain gene knockouts can restore the growth of otherwise nonviable gene-deficient cells. Many questions follow from this discovery: What ...
The identification of evidence-based, efficacious drug combinations for each cancer, among thousands of potential permutations, is a daunting task. In this perspective, we propose a systematic approach to defining such combinations by molecularly benchmarking a drug against a desired state of efficacy using model systems.
Treatment strategies are provided in accordance with the level of global cardiovascular risk, from lifestyle modification in the lower risk group to more comprehensive treatment in the higher risk group. Considering the common trend of combination drug regimen, the choice of the first drug is suggested more liberally according to the physician's discretion.
BACKGROUND Clinically relevant cutoffs are needed for the interpretation of HIV-1 phenotypic resistance estimates as predicted by "virtual" phenotype HIV resistance analysis. METHODS Using a clinical data set containing 2596 treatment change episodes in 2217 patients in 8 clinical trials and 2 population-based cohorts, drug-specific linear regression models were developed to describe the rela...
The classification of sugarcane varieties using products derived from remote sensing allows for the monitoring plants with different profiles without necessarily having physical contact study objects. However, differentiating between can be challenging due to similarity spectral characteristics each crop. Thus, this aimed classify four through deep neural networks, subsequently comparing result...
The two mass model (2MM) as introduced by Ishizaka & Flanagan (1972) and simplified by Steinecke & Herzel (1995) describes many features of the vocal fold oscillation patterns [1,2]. Particularly, it was shown that a large variety of voice disorders may be explained by means of high-speed observations with subsequent interpretation by the 2MM. Laryngeal symmetry was identified as an important p...
the most enigmatic problems with the nearly 200 salt domes pierced in the persian gulf and in the zagros mountain ranges (zmr) in southern iran, a unique morphology in the world, have been the matter of this study, which is based on a combination of field work, enhancement of satellite and aerial photographs etc. in the zmr, structural anomalies are frequently associated with similar facies dis...
Beta-lactams, in combination with beta-lactamase inhibitors, are reported to have activity against Mycobacterium tuberculosis bacteria growing in broth, as well as inside the human macrophage. We tested representative beta-lactams belonging to 3 different classes for activity against replicating M. tuberculosis in broth and nonreplicating M. tuberculosis under hypoxia, as well as against strept...
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