This article examines the required spatial discretization perpendicular to the fracture-matrix interface (FMI) for numerical simulation of solute transport in discretely fractured porous media. The discrete-fracture, finite-element model HydroGeoSphere (Therrien et al. 2005) and a discrete-fracture implementation of MT3DMS (Zheng 1990) were used to model solute transport in a single fracture, a...

The numerical simulation of non-smooth hybrid systems exhibiting chattering behavior requires high computational costs. In the worst case, the simulation appears to come to a halt, since infinitely many discrete transitions would need to be simulated. In this paper we present an FMI-based framework and prototypical implementation for robust and reliable detection and elimination “On the Fly” of...

This paper proposes a novel approach to detect and label objects within images and describes a two-player web-based guessing game – Ask’nSeek – that supports these tasks in a fun and interactive way. Ask’nSeek asks users to guess the location of a hidden region within an image with the help of semantic and topological clues. The information collected from game logs is combined with results from...

Co-Simulation is a general approach to simulate coupled technical systems. In a master-slave concept the slaves simulate sub-problems whereas the master is responsible for both coordinating the overall simulation as well as transferring data. To unify the interface between master and slave the FMI for CoSimulation was developed. Using FMI a master was implemented with simple and advanced algori...

El neoliberalismo implicó, desde la década de los setenta, una profunda reconfiguración las economías nacionales y un aumento significativo desigualdades. Fondo Monetario Internacional (FMI), que se autopercibe por encima derechos humanos, ha sido vehículo institucional central en este cambio, a través sus créditos condicionalidades frecuentemente traducen violaciones humanos poblaciones Estado...

Silvia Arber Biozentrum and FMI, Basel, Switzerland Silvia Arber is a Professor of Neurobiology at the Biozentrum of the University of Basel and aSenior Investigator at the Friedrich Miescher Institute (FMI) for Biomedical Research in Basel, Switzerland. Her laboratory investigates neuronal circuits controlling motor behavior. Current work aims to uncover the synaptic organization of motor circ...

During development, multiple environmental cues, e.g., growth factors, cell adhesion molecules, etc., interact to influence the pattern of outgrowth of axons and dendrites in a cell-specific fashion. As a result, individual neurons may receive similar signals, but make unique choices, leading to distinct wiring within the nervous system. C. elegans has been useful in identifying molecular cues ...

Accurate measurement of fat mass has become increasingly important with the increasing incidence of obesity. We assessed fat and muscle mass of Koreans with the Korea National Health and Nutrition Examination Survey IV (KNHANES IV). We studied 10,456 subjects (aged 20 to 85 yr; 4,476 men, 5,980 women). Fat and muscle mass were measured by dual-energy x-ray absorptiometry. Reference values of bo...

The Drosophila wing provides an appropriate model system for studying genetic programming of planar cell polarity (PCP) [1-4]. Each wing cell respects the proximodistal (PD) axis; i.e., it localizes an assembly of actin bundles to its distalmost vertex and produces a single prehair. This PD polarization requires the redistribution of Flamingo (Fmi), a seven-pass transmembrane cadherin, to proxi...

Esta investigación estima el peso de los sobrecargos que Fondo Monetario Internacional (FMI) espera cobrar a países deudores medianos ingresos durante 2023-2033. La evidencia indica no logran su supuesto objetivo incentivar pago anticipado las deudas; en cambio, incrementan la deuda prestatarios precisamente enfrentan problemas más graves balanza pago, mientras FMI se beneficia estas crisis.