Serum homocysteine, folic acid, lipoprotein (a) (Lp(a)), fibrinogen, and C-reactive protein (CRP) concentrations and erythrocyte sedimentation rates (ESR) were measured in 52 patients with familial Mediterranean fever (FMF) during attack-free periods and in 30 healthy control subjects. Serum homocysteine levels were significantly higher in the FMF patients (median 17.8 microg/dl; range 5.6-80.8...

OBJECTIVE To characterize the factors contributing to a greater than 10 year delay in the diagnosis of familial Mediterranean fever (FMF). METHODS 50 patients, in whom diagnosis of FMF was delayed by more than 10 years, comprised the study population. The clinical, demographic and molecular genetic characteristics were compared to a control group of 50 FMF patients, in whom the diagnosis was ...

Familial Mediterranean fever (FMF) is an inherited autosomal recessive disorder, ethnically restricted and commonly found among individuals of Mediterranean descent, caused by MEditerranean FeVer gene (MEFV) mutations on chromosome 16. It is the most frequent periodic febrile syndrome among the autoinflammatory syndromes. Clinically, FMF can be distinguished into three phenotypes: type 1, which...

Introduction Pyrin protein is the product of the MEFV gene, mutations in which cause the manifestation of Familial Mediterranean Fever (FMF). Complete tertiary structure of pyrin and the effects of mutations on it are still experimentally not studied. Mutations E148Q, M680I, M694V, M694I, V726A, A744S and R761H of pyrin induce manifestation of the most widespread and severe forms of FMF. One st...

OBJECTIVE The aim of this study was to evaluate the effectiveness of prenatal screening for trisomy 18 with the use of the frontomaxillary facial angle (FMF angle) measurement. MATERIAL AND METHODS The study involved 1751 singleton pregnancies at 11-13 + 6 weeks, examined between 2007 and 2011. Serum PAPP-A and free beta-hCG levels were assessed, and crown-rump length, nuchal translucency, an...

Background and question Similar to other autoinflammatory diseases, diagnosis of FMF is often missed and markedly delayed, particularly when its prevalance is very low in a community. It’s reported that diagnosis of FMF might be delayed more than 20 years. Although Turkey is one of the countries with a high prevalence of FMF, the diagnosis of the disease is markedly delayed in clinical practice...

Results Fifty six patients were included: 17 Cryopyrin-Associated Periodic Syndromes (CAPS), 4 TNF-Receptor-Associated Periodic fever Syndrome (TRAPS), 5 Hyperimmunoglobulinaemia D with periodic fever Syndrome (HIDS), 18 Familial Mediterranean Fever (FMF), 6 Chronic Recurrent Multifocal Osteomyelitis (CRMO), 2 Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO) syndrome and 4 Behçet’s D...

Introduction Familial Mediterranean Fever (FMF) is caused by mutations in the MEFV (Mediterranean FeVer) gene, which encodes pyrin. Phenotypic heterogeneity is very common in FMF patients and may partly rely on genetic heterogeneity. However, many cases having weak phenotypic-genotypic correlation, different clinical findings and therapeutic approaches with the same genotype show that FMF is no...

Introduction Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by periodic fever and polyserositis attacks. FMF can be associated with vasculitis, spondyloarthropaties, Behçet’s disease and inflammatory bowel disease. Psoriasis is another disease that can be associated with FMF. Psoriasis is a common disease affecting approximately 2% of the population. Although...

Methods Demographic data of FMF patients, followed in the national FMF center at Sheba medical center (n=8352) and Hadassah Medical Center (n=1083) were obtained from FMF patient hospital registries. The prevalence of cancer in the general population, and in the study registries was attained from the cancer registry of Israel and analyzed according to age, origin, and cancer type. The Standardi...