The usefulness of fluoroquinolones for the treatment of mixed aerobic and anaerobic infections has been investigated since these agents started being used in clinical practice. Newer compounds have increased in vitro activity against anaerobes, but clinically relevant susceptibility breakpoints for these bacteria have not been established. Pharmacodynamic analyses and corroboration by new data ...

Fluoroquinolones are broad-spectrum antibiotics that target gyrase and topoisomerase IV, involved in DNA compaction segregation. We synthesized 28 novel norfloxacin hydroxamic acid derivatives with additional metal-chelating hydrophobic pharmacophores,...

Fluoroquinolones are widely employed to treat or prevent respiratory diseases in poultry, and their residues could be present even after slaughtering. Thus, this study aimed assess the oxidative effect of fluoroquinolones on myosin chicken meat proteins under vitro conditions, using proteomics peptidomics approaches. Myosin was initially exposed ciprofloxacin sarafloxacin, which showed an incre...

BACKGROUND Case reports indicate that the use of fluoroquinolones may lead to acute kidney injury. We studied the association between the use of oral fluoroquinolones and acute kidney injury, and we examined interaction with renin-angiotensin-system blockers. METHODS We formed a nested cohort of men aged 40-85 enrolled in the United States IMS LifeLink Health Plan Claims Database between 2001...

Abstract DNA gyrase, a type II topoisomerase found predominantly in bacteria, is the target for variety of ‘poisons’, namely natural product toxins (e.g. albicidin, microcin B17) and clinically important synthetic molecules fluoroquinolones). Resistance to both groups can be mediated by pentapeptide repeat proteins (PRPs). Despite long-term studies, mechanism action these protective PRPs not kn...