Dengue diseases have an economic as well as social burden worldwide. In this study, the antiviral activity of protegrin-1 (PG-1, RGGRLCYCRRRFCVCVGR) peptide towards dengue NS2B-NS3pro and viral replication in Rhesus monkey kidney (MK2) cells was investigated. The peptide PG-1 was synthesized by solid-phase peptide synthesis, and disulphide bonds formation followed by peptide purification was co...

Statistical modelling and inference problems with sample sizes substantially smaller than the number of available covariates are challenging. This is known as large p small n problem. We develop nonlinear regression models in this setup for accurate prediction. In this paper, we introduce a full Bayesian support vector regression model with Vapnik’s 2-insensitive loss function, based on reprodu...

In this work, a multilayer dielectric optical notch filters design is proposed based on TiO2 and SiO2 alternating layers. Titanium dioxide (TiO2) is selected for its high refractive index value (2.5) and Silicon dioxide (SiO2) as a low refractive index layer (1.45). These filters are conventionally envisioned for overpowering of powerful laser beams in research experiments, to obtain good signa...

The present work attempts to carry out preliminary phytochemical screening, detailed pharmacognostic study and physicochemical evaluation of leaf of Crotalaria pallida. Crotalaria pallida Aiton. is a plant with vast medicinal properties. The plant has been traditionally used for the treatment of swelling of joints , fever , vermifuge, skin diseases and also The plant and its parts are reported ...

The signal and limitations of calcium florescence imaging using nonresonant multiphoton absorption of near-infrared femto- and picosecond laser pulses were examined. The fluorescence changes of various Ca(2+)-indicators induced by transient increases of the intradendritic calcium concentration were evaluated by evoking physiological activity in neocortical neurons in rat brain slices. Photodama...

Objective: To investigate the physico-chemical parameter, preliminary phytochemical screening, fluorescence and Thin Layer Chromatographic analysis of the leaves of the plant Lasia spinosa (Lour) Thwaites. Methods: The fresh and powder leaves of the plant Lasia spinosa (Lour) Thwaites (Araceae) were studied by morphology, preliminary phytochemical screening, and florescence analysis of powdered...

Clear cell sarcoma (CCS) is an uncommon tumor that usually presents as an extremity mass but can rarely manifest as a gastrointestinal tumor with a diverse spectrum of symptoms, most commonly related to a mass effect or ulceration. Herein we report a case in which two separate tumors, one in the duodenum and the other in the jejunum, present concurrently. The subject presented with symptomatic ...

OBJECTIVES 1-hydroxypyrene is an important biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), which appears in the urine of exposed human subjects. In developing countries, where advanced instruments are not available, the importance of this biomarker demands convenient and sensitive methods for determination purposes. This study aimed at developing a methodology to quantify 1-hy...

Cerium oxide nanocrystals (CeO2-NCs) exhibit superoxide dismutase and catalase mimetic activities. Based on these catalytic activities, CeO2-NCs have been suggested to have the potential to treat various diseases. The crystalline size of these materials is an important factor that influences the performance of CeO2-NCs. Previous reports have shown that several metal-based nanocrystals, includin...

Cytokinins and gibberellins (GAs) play antagonistic roles in regulating reproductive meristem activity. Cytokinins have positive effects on meristem activity and maintenance. During inflorescence meristem development, cytokinin biosynthesis is activated via a KNOX-mediated pathway. Increased cytokinin activity leads to higher grain number, whereas GAs negatively affect meristem activity. The GA...