ProductAbstractFactory ConcreteProductConcreteFactoryAbstractClientManager ModuleApplication 145USING FLEX 4Application architecture Last updated 11/5/2010Module domainsBy default, a module is loaded into a child domain of the current application domain. You can specify a differentapplication domain by using the applicationDomain property of the ModuleLoa...

A novel engineered antibody fragment (VL-VH-CH3, or "minibody") with bivalent binding to carcinoembryonic antigen (CEA) was produced by genetic fusion of a T84.66 (anti-CEA) single-chain antibody (scFv) to the human IgG1 CH3 domain. Two designs for the connecting peptide were evaluated. In the T84.66/212 LD minibody, a two-amino acid linker (generated by fusion of restriction sites) was used to...

AIMS To report our initial experience with femtosecond lenticule extraction (FLEX) compared with femtosecond laser-assisted in situ keratomileusis (LASIK). SETTINGS AND DESIGN This was a prospective pilot study carried out at the Refractive Surgery Department of the Beyoglu Eye Training and Research Hospital, Istanbul, Turkey. MATERIALS AND METHODS Surgery was performed on both eyes of 14 c...

web hosting service, web server cluster, load balancing, scalability, super linear speedup, performance analysis FLEX is a new cost effective, "locality aware" load balancing solution for a shared web hosting service implemented on a cluster of machines [C99]. FLEX allocates hosted web sites to different machines in the cluster based on the sites' processing and memory requirements which are es...

Cortical efferent and afferent fibers are arranged in a stereotyped pattern in the intermediate zone (IZ). Here, we studied themechanism of axonal pathway formation by identifying a molecule that is expressed in a subset of cortical axons in the rat. We found that T-cadherin (T-cad), a member of the cadherin family, is expressed in deep-layer cell axons projecting to subcortical structures, but...

Automatic iterative model (re-)building, as implemented in ARP/wARP and its new control system flex-wARP, is particularly well suited to follow structure solution by molecular replacement. More than 100 molecular-replacement solutions automatically solved by the BALBES software were submitted to three standard protocols in flex-wARP and the results were compared with final models from the PDB. ...

A novel engineered antibody fragment (VL-VH-CH3, or "minibody") with bivalent binding to carcinoembryonic antigen (CEA) was produced by genetic fusion of a T84.66 (anti-CEA) single-chain antibody (scFv) to the human IgGl CH3 domain. Two designs for the connecting peptide were evaluated. In the 184.66/212 LD inin¡body,a two-amino acid linker (generated by fusion of restriction sites) was used t...